注射用还原型谷胱甘肽对盆腔放疗致急性放射性肠炎预防作用的临床疗效观察

Efficacy observation of glutathione on prevention of acute radiation enteritis in pelvic radiation therapy

目的：探讨盆腔恶性肿瘤患者在盆腔放疗中使用注射用还原型谷胱甘肽对急性放射性肠炎的预防作用。方法将80例盆腔肿瘤放疗患者按数字表法随机分为治疗组40例和对照组40例，患者均根据放疗规范行术后辅助放疗；治疗组每次放疗后半小时内静脉滴注注射用还原型谷胱甘肽；对照组不使用注射用还原型谷胱甘肽；观察两组出现急性放射性肠炎的时间及急性放射性肠炎的分级情况。结果急性放射性肠炎出现的时间：治疗组：第2周有6例占15．0％，第3周有29例占72．5％；对照组：第2周有25例占62．5％，第3周有11例占27．5％；两组差异有统计学意义（χ^2＝18．775、15．998，均 P ＜0．001），治疗组多数患者（72．5％）在第3周开始出现急性放射性肠炎，而对照组多数患者（62．5％）在第2周就出现急性放射性肠炎，治疗组发生急性放射性肠炎的时间晚于对照组；急性放射性肠炎分级情况：治疗组：发生1级放射性肠炎的患者有31例占77．5％，发生2级放射性肠炎的患者有7例占17．5％；对照组：发生1级放射性肠炎的患者有8例占20．％；发生2级放射性肠炎的患者有29例占72．5％；两组差异均有统计学意义（χ^2＝26．136、24．139，均 P ＜0．001），治疗组多数患者（77．5％）发生1级急性放射性肠炎，而对照组多数患者（72．5％）发生2级急性放射性肠炎，治疗组多数患者急性放射性肠炎严重程度较对照组轻。结论注射用还原型谷胱甘肽可使急性放射性肠炎发生时间推迟，并能够减轻急性放射性肠炎的严重程度，值得临床上进一步探究。

Objective To observe the prevention effect of glutathione on acute radiation enteritis in pelvic radiation therapy.Methods All 80 pelvic tumor patients treated with radiotherapy were randomly assigned to the control group （40 patients）and the treatment group （40 patients）by the number table method.40 cases in the con-trol group treated with radiation were not treated with preventive drugs,but the patients in the treatment group were treated with glutathione.The occurrence time of acute radiation enteritis and the severity of acute radiation enteritis after treatment were evaluated.Results 15.0% of the treatment group suffered from acute radiation enteritis in the second week and 72.5% in the third week.however,62.5% of the control group were suffered from acute radiationenteritis in the second week and 27.5% in the third week.The difference was statistically significant （χ^2 =18.775, 15.998,all P 〈0.001）.Glutathione delayed the occurrence time of acute radiation enteritis.The grade 1 and grade 2 acute radiation enteritis effective rate in the treatment group were 77.5% and 17.5%,and that in the control group were 20.0% and 72.5%,the difference between the two groups was significant（χ^2 =26.136,24.139,all P 〈0.001）.The glutathione could reduce the incidence of acute radiation enteritis extent.Conclusion Glutathione could delay the occurrence time of acute radiation enteritis and reduce the incidence of acute radiation enteritis extent.It is worth clinical application.