金银花与山银花主要有效成分含量比较

Comparative analyses of the main active ingredients of Lonicerae japonicae flos and ;Lonicerae flos

目的：通过测定金银花和山银花主要有效成分含量，比较两者的质量。方法按2015年版《中华人民共和国药典》金银花和山银花项下收载的含量测定方法，对50批不同产地金银花、山银花中绿原酸、木犀草苷、灰毡毛忍冬皂苷乙和川续断皂苷乙含量进行测定。结果金银花木犀草苷含量较高，绿原酸含量较低，不含或少含皂苷类成分。山银花的主要基源灰毡毛忍冬、红腺忍冬的绿原酸、总皂苷含量较高，少含或不含木犀草苷。结论金银花与山银花的主要成分含量各有特色，部分金银花样品中皂苷含量较高，用作注射剂原料时，应做皂苷限量检查。

Objective To compare the quality of Lonicerae flos and Lonicerae japonicae flos by determine the main active ingredients. Methods According to methods and standards of determination in Chinese Pharmacopoeia （2015 Edition）, the content of chlorogenic acid , galuteolin , macranthoidin B and asperosaponin B in 50 batches of samples of Lonicerae japonicae flos and .Lonicerae flos were determined. Results For Lonicerae japonicae flos （Lonicera japonica Thunb.）, the contents of galuteolin was higher, and chlorogenic acid was lower, less or no contain saponins. For the main species of Lonicerae flos （Lonicera macranthoides Hand.-Mazz. and Lonicera hypoglauca Miq.）, the contents of chlorogenic acid and the sum of saponins were higher, less or no galuteolin. Conclusions The main active ingredients of Lonicerae japonicae flos and Lonicerae flos were different. The contents of saponins in some samples of Lonicerae japonicae flos were higher, so the test of saponin should be considered when its raw material for injection.