血清性激素、5-HT水平与围绝经期妇女抑郁焦虑的关系

The relationship of Serum sex hormone, 5-HT levels of anxiety and depression in perimenopausal women

目的探讨血清性激素、5-羟色胺(5-HT)水平与围绝经期妇女抑郁焦虑的关系。方法2015年4月至2016年4月选取180例无躯体器质性病变及其它精神障碍疾病的围绝经期妇女为调查研究对象,根据焦虑自评量表(SAS)及抑郁自评量表(SDS)将调查对象分为对照组(n=54),抑郁组(n=38),焦虑组(n=42)及抑郁焦虑共病组(n=46),测定各组血清中雌二醇(E2)、孕酮(P)、垂体催乳素(PRL)、卵泡生成素(FSH)、睾酮(T)及黄体生成素(LH)、5-羟色胺(5-HT)水平。结果四组血清FSH、LH、PRL水平比较无统计学差异(P>0.05),四组血清E2、P、T、5-HT水平比较有统计学差异(P<0.05)。经Pearson相关系数分析,围绝经期妇女血清P与SDS评分、SAS评分呈负相关(P<0.05),血清T与SDS评分、SAS评分呈正相关(P<0.05),血清5-HT与SDS呈正相关(P<0.05)。结论性激素与围绝经期抑郁焦虑的发生有密切的关系,5-HT可与性激素共同影响抑郁症的发生。

Objective To investigate the relationship of Serum sex hormone, 5-HT levels of anxiety and depression in perimenopausal women. Methods 180 cases of non-organic disease and other physical disorders in perimenopausal women were divided into control group （n = 54）, depression group （n = 38）, anxiety group （n=42） and comorbid depression and anxiety group （n=46） based on self-rating anxiety scale （SAS） and Self-Rating Depression Scale （SDS） from April 2015 to April 2016. The levels of estradiol （E2）, progesterone （P）, prolactin （PRL）, follicle stimulating hormone （FSH）, testosterone （T）, luteinizing hormone （LH） and 5-HT were determed. Results The levels of FSH, LH, PRL of four groups were had no significant difference （P 〉 0.05） The levels of E2 、 P 、 T 、 5-HTof four groups had significant difference （P 〈 0.05）. Pearson correlation coefficient, serum P had negatively correlation with SDS, SAS （P 〈 0.05）, serum T had positively correlation with SDS, SAS （P 〈 0.05）, serum 5-HT and SDS was positively correlated （P 〈 0.05）. Conclusion Hormone perimenopausal depression and anxiety occur are closely related, 5-HT and sex hormones may affect the common occurrence of depression.