急性心肌梗死经皮冠状动脉介入治疗后伴焦虑抑郁患者ET-1、PAI-1及hs-CRP浓度分析

ET-1, PAI-1 and hs-CRP concentration analysis of AMI complicated with anxiety and depression after PCI

目的测定急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI术)后的内皮素-1(ET-1)、人纤溶酶原激活物抑制因子-1(PAI-1)以及高敏C反应蛋白(hs-CRP)浓度,并分析AMI术后伴焦虑抑郁对ET-1、PAI-1及hs-CRP水平的影响。方法选取我院2013年9月至2015年9月期间在接受PCI术治疗的AMI患者200名,按照汉密尔顿焦虑及抑郁量表评分将患者分成介入术后伴焦虑抑郁组(n=103)和介入术后无焦虑抑郁组(n=97)。另选100例未行PCI术治疗患者(对照组)。应用ELASE法测定血清当中内ET-1、PAI-1水平,采用速率散射比浊法测定血清当中hsCRP水平,并对数据进行统计分析。结果 PCI术患者血清ET-1、PAI-1及hs-CRP水平明显高于对照组,且术后伴焦虑抑郁患者明显高于术后无焦虑抑郁的患者。结论 PCI术和焦虑抑郁状态均可能影响患者ET-1、PAI-1及hs-CRP水平。

Objective To determine the ET-1, PAI-1 and hs-CRP concentration of AMI （acute myocardial infarction） complicated with anxiety and depression after PCI （percutaneous coronary intervention）, and analyze influence of the anxiety and depression after PCI on ET-1, PAI-1 and hs-CRP levels. Methods 200 cases of PCI patients in our hospital from September 2013 to September 2015 were divided into the group with anxiety and depression （n=103） and the group without anxiety and depression （n=97） accordding scores of HAMA and HAMD. 100 cases without any PCI were taken as the control group. ELASE method was applied in the determination of serum ET-1 and PAI-1 level, rate scatter turbid assays was used for the determination of serum hs-CRP level. Results The serum ET-1, PAI-1 and hs-CRP levels of PCI patients were significantly higher than those of the control group, and the serum ET-1, PAI-1 and hs-CRP levels of PCI patients combined with anxiety and depression were significantly higher than PCI patients without anxiety and depression. Conclusion PCI technique and the state of anxiety and depression may have significant impact on serum ET-1, PAI-I and hs-CRP levels.