超声对青年肥胖型高血压患者颈动脉内中膜厚度的相关临床研究

Clinical Study of the Correlation between Carotid Intima-Media Thickness and Young Obese Hypertensive Patients by Using Ultrasound

目的探讨肥胖型原发性高血压青年患者颈动脉内中膜厚度的变化,并探讨肥胖因素及血压因素在青年人群血管病变中的权重。方法应用高分辨率超声测量检测40例青年肥胖型高血压组、40例青年正常体重高血压组、40例青年肥胖型正常血压组、及40例对照组的颈动脉内中膜厚度(Carotid intima-media thickness,CIMT)。结果青年肥胖型高血压组与对照组比较,CIMT增厚均高于对照组,差异有统计学意义(P<0.05),青年正常体重高血压组CIMT增厚均高于对照组,差异有统计学意义(P<0.05),青年肥胖型正常血压组各部位CIMT增厚与对照组比较无统计学差异(P>0.05)。3组各部位的CIMT增厚比率均高于对照组(P<0.01)。青年肥胖型高血压组CIMT增厚比率与青年正常体重高血压组比较,其差异有统计学意义(P<0.05)。青年肥胖型高血压组、青年正常体重高血压组、青年肥胖型正常血压组的CIMT增厚比率比较具有统计学意义(P<0.05)。高血压和肥胖两者同时存在时,与CIMT增厚具有明显相关性,差异有统计学意义(P<0.01)。结论青年人肥胖和原发性高血压与颈动脉内中膜厚度关系密切,肥胖因素及血压因素在青年CIMT中具有明显相关性。

Objective To study the changes in carotid artery intima-media thickness（CIMT） for young obese patients with essential hypertension and to explore the weights of obesity and blood pressure factors in vascular lesions among young population. Methods CIMT of Young Obese Hypertension Group（40 cases）, Young Normal Weight Hypertension Group（40 cases）, Young Obese Normal Blood Pressure Group（40 cases） and Control Group（40 cases） was measured by using high-resolution ultrasonography. Results The thickening of CIMT of Young Obese Hypertension Group and Young Normal Weight Hypertension Group was higher than that of Control Group, with statistically significant difference respectively（P 〈0.05）. The thickening of CIMT of Young Obese Normal Blood Pressure Group was higher than that of Control Group, with statistically significant difference（P〈0.05）. The thickening of CIMT in each location of Young Obese Hypertension Group, Young Normal Weight Hypertension Group and Young Obese Normal Blood Pressure Group was higher than that of Control Group. The thickening of CIMT of Young Obese Hypertension Group was higher than that of Young Normal Weight Hypertension Group, with statistically significant difference respectively（P0.05）.The statistically significant difference was seen between the thickening ratio of CIMT of Young Obese Hypertension Group, Young Normal Weight Hypertension Group and Young Obese Normal Blood Pressure Group（P〈0.05）. For patients with both obesity and hypertension, an obvious correlation was found between obesity, hypertension and the thickening of CIMT, with statistically significant difference（P〈0.01）. Conclusion Essential hypertension and obesity among young people were closely related to CIMT, obesity and blood pressure factors had obvious correlation with CIMT for young people.