经颅直流电刺激配合心理干预对产褥期抑郁症患者的影响

Effect of transcranial direct current stimulation combined with psychological intervention on patients with PPD

目的:观察经颅直流电刺激(tDCS)配合心理干预对产褥期抑郁症(PPD)患者的临床疗效。方法:120例PPD患者随机分3组各40例。tDCS组给予tDCS治疗,心理干预组给予心理干预治疗,综合组给予tDCS配合心理干预治疗。采用抑郁症自评量表(SDS)、焦虑症自评量表(SAS)及汉密尔顿抑郁量表(HAMD)评定并观察治疗后的临床疗效。结果:治疗6周后,3组SAS、SDS及HAMD评分均较治疗前明显下降(P<0.01),且综合组各项评分均更低于tDCS组和心理干预组(P<0.01);心理干预组SAS及SDS评分更低于tDCS组(P<0.01),HAMD评分2组间比较差异无统计学意义。治疗后,综合组总有效率明显高于心理干预组及tDCS组(97.5%、85.0%及82.5%,P<0.05),tDCS组与心理干预组比较差异无统计学意义。结论:tDCS结合心理干预治疗能明显提高产后抑郁患者的临床疗效,值得临床推广。

Objective：To observe the transcranial direct current stimulation （tDCS）to cooperate with the clinical curative effect of psychological intervention on patients with postpartum depression （PPD）.Methods：Using ran-domized method,120 patients with PPD were randomly divided into three groups,40 cases in each group.The tDCS group was given tDCS,psychological intervention group was given psychological intervention,and combination group was given psychological intervention and tDCS.After treatment for 6 weeks,the clinical curative effect, SDS,SAS and HAMD scores were observed.Results：After treatment for 6 weeks,the SAS,SDS and HAMD scores in all three groups were significantly reduced as compared with those before treatment （P 〈0.01）.The SAS, SDS and HAMD scores in combination group were significantly lower than in tDCS group and intervention group （P 〈0.01 ）.The SAS and SDS scores were significantly lower in the intervention group than in the tDCS group （P 〈0.01 ）.There was no significant difference in the HAMD scores between the tDCS group and intervention group.After treatment,the total effective rate in the combination group was significantly higher than in the inter-vention group and tDCS group （97.5% vs .85.0% vs .82.5%,P 〈0.05）,but there was no significant difference between the tDCS group and intervention group.Conclusions：The tDCS combined with psychological intervention can significantly improve the clinical curative effect of patients with PPD,decrease the HAMD scores,and signifi-cantly reduce SAS and SDS scores.