长期吸烟慢性阻塞性肺疾病患者炎症因子表达水平与体质量指数的相关性研究

Correlation between expression levels of inflammatory factors and body mass index in COPD patients with chronic smoking

目的 探讨有长期吸烟史的COPD患者其血液中各个炎症因子（IF）的水平与体质量指数（BMI）间的相关性。方法 选取我院自2014年8月至2015年8月间收治的稳定期COPD患者56例作为观察组,选取同时期进行身体检查的健康人40例作为对照组,分别测定2组研究对象血清中C反应蛋白（CRP）、肿瘤坏死因子α （TNF-α）、瘦素的表达量,同时测定2组研究对象的BMI,分析各炎性因子与BMI之间的关系。结果 观察组患者瘦素、TNF-α和CRP水平[（6.75±1.16）μg/L,（9.13±2.77）ng/L,（11.07±3.44）mg/L]高于对照组[（4.64±1.17）μg/L,（5.26±2.61）ng/L,（3.89±2.52）mg/L]（P〈0.05）。BMI＆gt;18.5kg/m2 的COPD患者其瘦素表达量[（9.96±0.87）μg/L]明显低于BMI≤18.5kg/m2 患者组[（11.05±0.74）μg/L],数据对比差异有统计学意义（P〈0.05）;而TNF-α和CRP 的表达量2组之间差异无统计学意义（P〉0.05）。结论 长期吸烟史COPD患者体内的炎性因子表达量明显升高,其中瘦素会影响患者的BMI指标。

Objective To investigate the correlation between the levels of various inflammatory factors （IF） and body mass index （BMI） in the blood of patients with chronic obstructive pulmonary disease （COPD）, which has a long history of smoking. Methods From August 2014 to August 2015,56 cases of COPD patients were selected as the observation group in our hospital. At the same time, 40 healthy people as control group were selected as the control group. The serum levels of C-reactive protein （CRP）, tumor necrosis factor-a（TNF-~） and Leptin （LP） were measured in two groups. The BMI of the two groups was measured, and the relationship between the inflammatory factors and BMI was analyzed. Results Compared to healthy people in stable COPD patients in the observation group the serum CRP and TNF-a levels were significantly higher, but with BMI in patients with no correlation. LP group was significantly higher than the control, the data had significant differences （ P〈0.05）, and BMI showed negative correlation. Conclusions The expression of inflammatory factors in COPD patients with chronic smoking history was significantly increased, the BMI index of the patients with leptin.