新型佐剂MF59和AS03在流感疫苗中的应用

Application of new generation adjuvants MF59 and AS03 in influenza vaccines

佐剂能增强流感疫苗的免疫效果,除了经典的铝佐剂,一些新型流感疫苗佐剂也已应用于人体,如水包油乳剂MF59、AS03.它们不仅与经典铝佐剂的抗体诱导能力相当,还能诱导特异性细胞免疫应答.此文就流感疫苗新型佐剂的组成、作用机制、临床试验进行总结和分析,并对佐剂研究的进一步发展提出思考和见解.

Adjuvants can increase the immune response to influenza vaccines.Besides the classic aluminum adjuvant,several new adjuvants,including MF59 and AS03,have been licensed for human use.They have shown improved efficacy for cell-mediated response,and also have a humoral immunity profile similar to aluminum.This article outlines the composition,mode of action and clinical efficacy of new generation influenza vaccine adjuvants.Thoughts and proposals on further development of adjuvants are also addressed.