摘要
Background：Meniere＇s disease is a unique,progressive disease of the inner ear.The complex manifestation presents diagnostic challenges.The cochlear symptoms often present before vertigo and tend to be ignored.This study aimed to analyze the characteristics of cochlear symptoms and functions associated with Meniere＇s disease to investigate the regularity of the development of this disorder.Methods：One-hundred fifteen patients who were diagnosed with definite unilateral Meniere＇s disease at the Hearing and Vestibular Clinic of the Department of Otorhinolaryngology of Beijing Tongren Hospital from August 2013 to November 2015 were recruited in this retrospective study.Initial symptoms,duration from initial symptoms to the diagnosis,hearing thresholds,audiogram patterns,and caloric test results were collected and analyzed for each patient.Data were analyzed using SPSS 13.0 statistical software by Spearman＇s correlation,Kruskal-Wallis H test,Chi-square test,and Fisher＇s exact test.Results：The average hearing threshold of these patients was 45.24 ± 18.40 dB HL.A majority of the patients （55.65%） were in Stage 3.The initial presentation of the disorder in 58 cases （50.43%） comprised only cochlear symptoms without vertigo.A weak,positive correlation was found between the degree of hearing loss and duration of the disease from initial symptoms to the diagnosis （rs =0.288,P =0.002）.Upward-sloping,inverted ＂V,＂ downward-sloping,and flat pattern were the main audiometric patterns observed with a distinctive distribution between stages （P 〈 0.001）.Based on the configurations of audiograms,the audiometric patterns had a weak correlation to the duration （rs =0.269,P =0.004）,and there was a tendency of duration to rising from upward-sloping,inverted ＂V＂,downward-sloping to flat pattern.（H =10.024,P =0.018）.Frequencies of tinnitus in 56 patients （64.4%） were at the lowest points of the audiograms,i.e.,the frequencies of the poorest hearing threshold.The patients at an advanced stage （Stage 3 [56] and Stage 4 [73]） exhibited a significantly higher abnormality of canal paresis than those at the earlier stages （Stage 1 [23] and Stage 2 [42]） （χ^2 =5.973,P=0.015）.Conclusions：Patients with definite Meniere＇s disease always have a moderate to severe sensorineural hearing loss before diagnosis.Cochlear symptoms are the most common initial presentation.With the progression of the duration,the hearing impairment becomes more severe and the distribution of the audiometric pattem is distinctive between stages.
Background：Meniere＇s disease is a unique,progressive disease of the inner ear.The complex manifestation presents diagnostic challenges.The cochlear symptoms often present before vertigo and tend to be ignored.This study aimed to analyze the characteristics of cochlear symptoms and functions associated with Meniere＇s disease to investigate the regularity of the development of this disorder.Methods：One-hundred fifteen patients who were diagnosed with definite unilateral Meniere＇s disease at the Hearing and Vestibular Clinic of the Department of Otorhinolaryngology of Beijing Tongren Hospital from August 2013 to November 2015 were recruited in this retrospective study.Initial symptoms,duration from initial symptoms to the diagnosis,hearing thresholds,audiogram patterns,and caloric test results were collected and analyzed for each patient.Data were analyzed using SPSS 13.0 statistical software by Spearman＇s correlation,Kruskal-Wallis H test,Chi-square test,and Fisher＇s exact test.Results：The average hearing threshold of these patients was 45.24 ± 18.40 dB HL.A majority of the patients （55.65%） were in Stage 3.The initial presentation of the disorder in 58 cases （50.43%） comprised only cochlear symptoms without vertigo.A weak,positive correlation was found between the degree of hearing loss and duration of the disease from initial symptoms to the diagnosis （rs =0.288,P =0.002）.Upward-sloping,inverted ＂V,＂ downward-sloping,and flat pattern were the main audiometric patterns observed with a distinctive distribution between stages （P 〈 0.001）.Based on the configurations of audiograms,the audiometric patterns had a weak correlation to the duration （rs =0.269,P =0.004）,and there was a tendency of duration to rising from upward-sloping,inverted ＂V＂,downward-sloping to flat pattern.（H =10.024,P =0.018）.Frequencies of tinnitus in 56 patients （64.4%） were at the lowest points of the audiograms,i.e.,the frequencies of the poorest hearing threshold.The patients at an advanced stage （Stage 3 [56] and Stage 4 [73]） exhibited a significantly higher abnormality of canal paresis than those at the earlier stages （Stage 1 [23] and Stage 2 [42]） （χ^2 =5.973,P=0.015）.Conclusions：Patients with definite Meniere＇s disease always have a moderate to severe sensorineural hearing loss before diagnosis.Cochlear symptoms are the most common initial presentation.With the progression of the duration,the hearing impairment becomes more severe and the distribution of the audiometric pattem is distinctive between stages.
