HER2的表达及其分子影像的研究进展

Research and development of HER2 expression molecular imaging

人表皮生长因子受体2（HER2）是一种具有酪氨酸激酶活性的跨膜受体,同时也是一种高表达于各种癌细胞的生物标志物.高表达HER2的肿瘤往往预后不良.HER2分子影像主要是利用放射性核素、磁性材料、发光物质等标记配体能与HER2特异性结合的特性,对患者体内HER2高表达病灶进行显像,从而协助HER2阳性疾病的诊断,筛选出抗HER2治疗有效的患者,并可用于疗效评估,是近年来肿瘤精准医疗研究的热点之一.

Human epidermal growth factor receptor-2 （HER2） is a kind of transmembrane receptor with tyrosine kinase activity,and also is a biomarker highly expressed in various cancer cells,often indicating poor clinical prognosis.HER2 expression molecular imaging mainly utilizes the labeled-ligands＇ ability of specific binding with HER2,such as radionuclide,magnetic materials and fluorescent substances,by which the high-HER2 expressed lesions are shown.This technique provides a strong support for diagnosing HER2-expressed diseases,selecting patients who are respondent to HER2-targeted therapy and evaluating the therapeutic effect,and has become one of the hot spots in the research of precise treatment of tumors in recent years.