羟考酮复合丙泊酚在无痛取卵术中的应用

Application of oxycodone hydrochloride combined with propofol in painless oocyte retrieval

目的观察羟考酮复合丙泊酚用于无痛取卵术的镇痛效果及安全性。方法选择我院门诊行无痛取卵术患者100例,年龄20~40岁,体重45~75kg,ASAⅠ或Ⅱ级,按随机数字表法分为两组：羟考酮复合丙泊酚组（A组）和单纯丙泊酚组（B组）,每组50例。A组缓慢静脉注射羟考酮0.1mg/kg（生理盐水稀释至5ml）,B组静脉注射等量生理盐水,5min后均静脉注射丙泊酚1.5~2mg/kg。苏醒时间、手术操作时间、丙泊酚用量、术后30min VAS评分和不良反应发生情况。结果术中丙泊酚用量A组为（121±18）mg,明显少于B组的（165±21）mg（P〈0.05）。术后VAS评分A组为（1.5±0.8）分,明显低于B组的（3.2±0.7）分（P〈0.05）。体动反应A组有8例（16%）,明显少于B组的30例（60%）（P〈0.05）。结论羟考酮复合丙泊酚可安全用于无痛取卵术并能减少丙泊酚用量,减轻术后疼痛。

Objective To investigate the effect and safety of oxycodone hydrochloride combined with propofol for patients underwent painless oocyte etrieval.Methods Patients who underwent painless oocyte retrieval 100 cases,falling into ASA grade Ⅰ or Ⅱ catergory,aged 20 to 40years old,weighing 45-75 kg,were randomly divided into group A and group B,50 patients in each group,according to random number tables.Group A were injected slowly oxycodone hydrochloride 0.1mg/kg（diluted to 5ml of normal saline）,and group B saline.All patients were injected propofol 1.5-2mg/kg after 5 min.Recovery time,operation time,propofol consumption,post-operative 30 min VAS scores and side effects were recorded accordingly.Results The propofol consumption（121±18）mg in group A was significantly less than that in group B（165±21）mg（P〈0.05）.The VAS scores（1.5±0.8）score in group A was lower than that in group B（3.2±0.7）score（P〈0.05）.The movement response occurred in 8（16%）and 30（60%）patients in group A and group B（P〈0.05）,respectively.Conclusion Oxycodone hydrochloride combined with propofol can be safely used for painless oocyte retrieval and reduce propofol consumption,relieving postoperative pain.