血清降钙素原和C-反应蛋白对子痫前期的临床诊断价值

Clinical diagnostic values of serum procalcitonin and C-reactive protein in patients with preeclampsia and prognosis analysis

目的检测子痫前期血清降钙素原(PCT)和C-反应蛋白(CRP)水平,为子痫前期的临床诊断、严重程度及预后评估提供依据。方法选择2015年1月-2015年10月吉林省妇幼保健院子瘤前期患者80例(研究组),轻度、重度各40例,随机选取同期正常妊娠晚期孕妇50例(正常对照组)。结果研究组患者血清PCT、CRP及阳性率分别为(2.38±0.57)μg/L、(22.96±1.13)mg/L和88.75%、83.75%,均高于正常对照组,差异有统计学意义(P<0.05);严重患者血清PCT、CRP及阳性率分别为(3.45±1.17)μg/L、(24.24±1.20)mg/L和95.00%、90.00%,均高于轻度患者,差异有统计学意义(P<0.05),研究组治疗后患者血清PCT、CRP及阳性率分别为(0.52±0.36)μg/L、(8.05±0.79)mg/L和10.00%、6.25%,均低于治疗前,治疗前后比较,差异有统计学意义(P<0.05)。结论子痫前期患者血清PCT、CRP显著升高,且随着严重程度而上升,治疗后血清PCT、CRP均下降,有助于子痫前期患者的早期诊断和预后评估。

Objective To detect the levels of serum proealcitonin （PCT） and C-reactive protein （CRP） in patients with preeelamp- sia, provide a basis for clinical diagnosis, degree of severity, and prognosis evaluation of preeclampsia. Methods Forty patients with mild preeelampsia and forty patients with severe preeclampsia were selected from the hospital from January to October in 2015 as study group. Fifty normal late pregnant women during the same period were randomly selected as control group. Results The levels and positive rates of serum PCT and CRP in study group were （2. 38±0. 57） μg/L, （22.96±1.13） mg/L and 88. 75%, 83. 75%, respectively, which were statisti- cally significantly higher than those in control group （ P〈0. 05 ） ; in study group, the levels and positive rates of serum PCT and CRP among the patients with severe preeelampsia were （3.45±1.17） μg/L, （24. 24±1.20） mg/L and 95.00%, 90. 00%, respectively, which were statistically significantly higher than those among the patients with mild preeclampsia （P〈0. 05 ） ; in study group, the levels and positive rates of serum PCT and CRP after treatment were （0. 52±0. 36）μg/L, （8.05±0. 79） mg/L and 10. 00%, 6. 25%, respectively, which were statistically significantly lower than those before treatment （ P〈0.05 ） . Conclusion The levels of serum PCT and CRP among patients with preeclampsia increase significantly, which increase with aggravation of the disease ; the levels of serum PCT and CRP after treatment de- crease, which is contribute to early diagnosis and prognosis evaluation of patients with preeclampsia.