瘦素、脂代谢紊乱与妊娠期糖尿病的关系

Relationship between leptin,lipid metabolic disorder and gestational diabetes mellitus

目的:探讨瘦素(Leptin)和脂代谢紊乱在妊娠期糖尿病(GDM)发病中的相互关系及意义。方法:实验分为GDM组、正常妊娠组、正常未孕组,检测血脂、空腹血糖、空腹胰岛素、血清瘦素及胎盘瘦素等指标,计算胰岛素抵抗指数(HOMA-IR)。结果:(1)GDM组血清瘦素、总胆固醇(TC)、甘油三酯(TG)、HOMAIR和胎盘瘦素含量高于NGT组,NGT组血清瘦素、TC和HOMA-IR高于对照组,差异有统计学意义(P<0.05);(2)血清瘦素分别与体质指数(body mass index,BMI)、HOMA-IR、TC和TG呈正相关(r分别为0.593、0.688、0.722、0.492,P<0.05)。结论 :瘦素可能通过引起脂代谢紊乱,进而两者共同参与GDM的发病、母体血清瘦素水平有望成为GDM的观察指标。

Objective To discuss the relationship between and value of Leptin with disorder of lipid metabolism in gestational diabetes mellitus. Method Research objects are divided into three groups including GDM group, normal glucose tolerance group （NGT group）, normal non-pregnant group. Blood lipid, fasting blood glucose, fasting insulin, serum leptin and placental leptin levels were detected and HOMA-IR was calculated. Result （1） Serum leptin, TC, TG, placental leptin and HOMA-IR in GDM group were higher than those of NGT group and TC, serum leptin and HOMA-IR of NGT group were higher than those of control group. There were statistical significances （P〈0.05）. （2）Serum leptin levels were positively correlated with BMI, HOMA-IR, TC and TG respectively （r = 0.593, 0.688, 0.722, 0.492 respectively, P 〈 0.05）. Conclusion Leptin may cause lipid metabolism disorders, and together they participate in the pathogenesis of GDM. Maternal serum leptin level is expected to become an observation index of GDM.