Slug在甲状腺乳头状癌中的表达及其临床意义

Expression and significance of Slug in papillary thyroid carcinomas

目的:观察甲状腺乳头状癌(PTC)及其癌旁组织中Slug蛋白的表达,并探讨其临床意义。方法:采用VENTANA自动免疫组化仪检测107例PTC及癌旁正常甲状腺组织中Slug蛋白的表达,观察其在PTC中的表达及其与各临床病理参数之间的关系。结果:PTC及癌旁甲状腺组织中Slug表达的阳性率分别为65.4%(70/107)、14.0%(15/107),两者比较差异有统计学意义(P<0.001)。PTC中Slug蛋白的高表达与癌的被膜侵犯和淋巴结转移情况相关(P<0.05)。结论:Slug蛋白在PTC中高表达,并且与包膜侵犯和淋巴结转移相关,推测其在判断肿瘤的转移和预后方面有一定的临床意义。

Objective To explore the clinical significance of Slug expression in papillary thyroid carci-noma（PTC）. Methods Employed Ventana immunohistochemistry assay to determine the expression of Slug in 107 cases of PTC and para-tumorous normal tissue. The relationship with Slug expression in PTC and clinico-pathology data were also analyzed. Results Expression of Slug in PTC （65.4%, 70/107）and para-tumorous nor-mal tissue （14.0%,15/107）were statistically different （P 〈 0.001）. Overexpression of Slug in PTC was signifi-cantly associated with capsular invasion and lymph node metastasis （P 〈 0.05）. Conclusion Overexpression of Slug in PTC is associated with capsular invasion and lymph node metastasis , these may suggest some clinical significance of Slug expression in PTC in predicting lymph node metastasis and prognosis.