晚期结直肠癌的超选择性动脉化疗栓塞治疗

Superselective artery infusion chemo-embolization for advanced colorectal carcinoma

目的探讨采用超液态碘化油+化疗药物治疗晚期结直肠癌的近期疗效及安全性。方法对50例结直肠癌患者行超液态碘化油+化疗药物超选择性化疗栓塞;伴转移者同时行转移灶化疗栓塞。观察介入术后患者症状改善情况、瘤体大小变化及并发症;介入术后可接受外科手术切除者,观察术中瘤体切除情况。结果介入术后1个月复查,部分缓解41例,病情稳定7例,疾病进展2例,无完全缓解患者;有效率82.00%(41/50)。12例患者行瘤体切除手术,外科术中可见瘤体活动度增加,与周围组织界限清晰。介入术后患者临床症状均明显改善,未出现肠穿孔等严重并发症。结论采用超液态碘化油+化疗药物行化疗栓塞可安全、有效地控制结直肠癌,增加晚期结直肠癌的手术机会,同时行转移灶介入治疗疗效确切。

Objective To evaluate the efficacy and safety of the chemo-embolization on colorectal cancer treated with lipiodol. Methods A total of 50 colorectal cancer patients accepted chemo-embolization. Patients with metastasis were also treated by transcatheter arterial chemoembolization. Symptomatic improvement, the response of tumors and complications were also observed. The condition of the patients undergoing tumors resection were observed. Results Partial response was in 41 cases, stable disease was in 7 cases, progressive disease was in 2 cases, and no complete response was found. The effective rate was 82.00% （41/50）. Twelve patients including 2 liver metastasis patients were performed surgery. During the operation, the tumors had a clear boundaries around the organization as well as the elevation of the mobility. Clinical symptoms of all patients were obviously improved, all the patients did not appear serious complications such as perforation. Conclusion The chemo-embolization therapy on colorectal cancer with lipiodol is feasible, safe and effective, which can also provide more surgery opportuniies, and metastases can also be controlled.