microRNA海绵在癌症中的研究进展

Progress of micro RNA sponge in cancer

mi RNA是一类长约22个核苷酸的非编码小RNA,广泛参与生物发育、细胞分化、细胞凋亡等多种生命进程。mi RNA海绵能够作为mi RNA有效抑制剂,是mi RNA缺失功能研究的重要工具。目前的研究发现,能起mi RNA海绵作用的有长链非编码RNA、环状RNA等。本文就mi RNA海绵在癌症中的研究现状及人工海绵的构建策略作一综述。

MiRNAs are a class of single stranded small non-coding RNA with ~22 nucleotides, which are involved in a variety of life processes such as organism development, cell differentiation and apoptosis, and so on. Mi RNA sponges act a sponge binding to mi RNA resulting in inhibiting mi RNA. And mi RNA sponge are important tools in studying function of mi RNAs. Recent studies have found that non-coding RNAs, including long non-coding RNA and circular RNA, can play role of mi RNA sponge. Here, we will summarize progress of mi RNA sponge in cancer and the general methods of mi RNA sponge construction.