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血小板源性CXC-型趋化因子在动脉粥样硬化中的作用 被引量:2

The role of platelet-derived CXC-chemokines in atherosclerosis
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摘要 近年来动脉粥样硬化在我国逐渐增多,该病是动脉硬化的血管病中最重要的一种,是心肌梗塞和脑梗塞的主要病因,也是中老年人死亡的主要原因之一。在我国已经证实,血小板源性的趋化因子——尤其是CXC-型趋化因子在动脉粥样硬化形成中发挥重要作用。因此,了解趋化因子的作用机制,可以为临床治疗动脉粥样硬化提供新的思路以及治疗靶点。 In recent years, atheroscleros is gradually increased in our country. The disease is the most important kind of atherosclerotic vascular diseases, and is the main cause of myocardial infarction and cerebral infarction race. And it also is one of the leading causes of death in the elderly. It has been confirmed in our country that platelet-derived chemokines, especially the CXC-chemokines play an important role in atherosclerosis. Therefore, understanding the mechanism of the chemokines can offer new ideas for clinical treatment of atherosclerosis as well as therapeutic targets.
出处 《生命的化学》 CAS CSCD 2016年第5期621-624,共4页 Chemistry of Life
关键词 血小板 趋化因子 动脉粥样硬化 作用 platelet chemokines atherosclerosis role
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参考文献19

  • 1Aidoudi S, Bikfalvi A. Interaction of PF4 (CXCL4) with the vasculature: a role in atherosclerosis and angiogene-sis. Thromb Haemost, 2010, 104: 941-948.
  • 2Zaldivar MM, Panels K, Berres ML, et al. A non-redun-dant role of the platelet-derived chemokine CXCL4 (PF4) in experimental liver fibrosis. J Hepatol, 2009, 50: 111-119.
  • 3Gleissner CA. Platelet-derived chemokines in atherogen-esis: what's new? Curr Vase Pharmacol, 2012,10: 563-569.
  • 4Duchene J, von Hundelshausen P. Platelet-derived chemokines in atherosclerosis. Hamostaseologie,2015, 35: 137-141.
  • 5Gleissner CA, Iftach S,Christian E, et al. CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages. Circ Res, 2010, 106: 203-211.
  • 6韩朝鑫,王彦富,赵红燕,靳奇峰,林楠,张慧玲,李清贤.趋化因子RANTES与冠状动脉斑块易损性的相关性研究[J].临床心血管病杂志,2014,30(4):319-321. 被引量:7
  • 7Patsouras MD, Sikara MP, Grika EP, et al. Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome. J Autoimmun, 2015,65: 30-37.
  • 8Vandercappellen J, Damme JV, Struyf S. The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1 /PF-4var) in inflammation, angiogene-sis and cancer. Cytokine & Growth Factor Rev, 2011, 22: 1-18.
  • 9von Hundelshausen P, Petersen F, Brandt E. Platelet-de-rived chemokines in vascular biology. Thromb Haemost,2007, 97: 704-713.
  • 10Mehran G, Kaplan ZS, Imala A,et al. The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood, 2013, 121: 4555-4566.

二级参考文献49

  • 1陈步星,马凤云,罗维,谢文丽,赵希哲,孙淑红,王枫,郭旭梅,褚晓雯.光学相干断层成像在冠心病介入治疗中的应用价值[J].中华心血管病杂志,2006,34(2):130-133. 被引量:19
  • 2LI Q X, FU Q Q, SHI S W, et al. Ralationship beteen plasma inflammatory markers and plaque fibrous cap thickness determined by intravascular optical Coherence tomography[J]. Heart, 2010,96: 196- 20l.
  • 3KRAAUEVELD A, DEJAGER S C, DEJAERWJ, et al. Chemokine lligand 5 (CCL5/RANTES) and CC chemokine ligand-IS (CCLl8/PARC) are specific marker of refractory unstable angina pectorisand are transiently raised during serveischemic sysmptoms[J]. Circulation, 2007,116: 1931-194l.
  • 4NIELS R V, BRENDA K, GRAZIANO P, et al. Antigonism of RANTES receptors reduces atherosclerotic plaque formation in mice[J]. Circ Res, 2004,94: 253- 26l.
  • 5VIRAN S, NAMBI V, HOOGEVEEN R, et al. Ratationship between circulating levels of RANTES (regulated on activation, normal T-cell expressed, and secreted) and carotid plaque characteristics: the Atherosclerosis Risk in Communitiest Aklf') Carotid MRI Study[J]. Eur HeartJ, 2011,32 :459-468.
  • 6NAGHAVI M, LIBBY P, FALK E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I[]]. Circulation, 2003,108: 1664-1672.
  • 7Thamp P,Bradforda W,Joseph L,etal.The A2b adenosine receptorprotects against vascular injury[].Proceedings of the National Academy of Sciences of the United States of America.2008
  • 8Andress S,Jurgen B,Christian W.Chemokine-like functions of MIF inatherosclerosis[].Journal of Molecular Medicine.2008
  • 9Jurgen B,Regina K,Hong G L,etal.MIF is a noncognate ligand ofCXC chemokine receptors ininflammatory and atherogenic cellrecruitment[].Nature.2007
  • 10Crump MP,Gong JH,Loetscher P,et al.Solution structure and basis for functional activity of stromal cell-derived factor-1:dissociation of CXCR4 activition from binding and inhibition of HIV-1[].EMBO Journal.1997

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