应用开端同轴线仪器检测结直肠癌组织和评估肿瘤浸润深度

The open-ended coaxial line method for colorectal cancer detection and depth evaluation of tumor invasion

目的：验证开端同轴线仪器在射频下鉴别结直肠癌组织和结直肠正常组织、评估结直肠癌浸润肠壁深度的可行性。方法：自南方医科大学珠江医院手术室的98例手术切除的新鲜离体结肠/直肠癌标本来,应用开端同轴线仪器在50～500 MHz频率段分别检测标本的肿瘤浆膜面、肿瘤黏膜面以及手术切缘黏膜面的相对介电常数和电导率。标本在手术结束后送至病理科行病理切片检查。结果：肿瘤黏膜面的相对介电常数和电导率均比正常黏膜面高（P〈0.01）,对于肿瘤已经侵犯或突破浆膜层（≥T3期）的结直肠癌组织,

Objective To confirm whether the open-ended coaxial line is effective in detection of the differences in dielectric properties between colorectal cancer tissues and surrounding normal tissues and evaluation of the depth of tumor invasion. Methods The open-ended coaxial line system at frequencies ranging from 50 to 500 MHz in 98 freshly excised colorectal cancerous specimens obtained from the operating theatre of Zhujiang Hospital, was used to detect both the relative permittivity and conductivity on the serosal surface of the carcinoma nidus, the mucosa of the carcinoma nidus, and the mucosa of the surgical resection margin.Pathological examinations were conducted on each specimen after surgery. Results The values for relative permittivity and conductivity of the colorectal cancerous mucosa were significantly higher than those of the normal mucosa（P〈0.01）. For the tumor which had invaded or penetrated the serosa（stage ≥ T3）, the dielectric properties of both the cancerous serosa and mucosa were higher than the one restricted to muscularis propria or less intestine wall（stage〈 T3） over the measured frequency range, and there existed statistical differences at the common frequencies of 213 MHz and 426 MHz. Conclusion The open-ended coaxial line system may result in fast and effective diagnostic differentiation between cancerous and normal colorectal tissues as well as reasonable assessment of the tumor infiltration depth.