MACC1蛋白在鼻咽癌组织中的表达及与预后的关系

Expression of MACC1 in nasopharyngeal carcinoma and its relationship with prognostic significance

目的:探讨结肠癌转移相关基因1(metastasis-associated in colon cancer-1,MACC1)在鼻咽癌中的表达与其临床病理特征和预后之间的关系。方法:采用免疫组化法检测130例鼻咽癌组织中MACC1蛋白的表达情况,分析MACC1蛋白在鼻咽癌组织的表达与临床病理特征及预后的关系。结果:MACC1在鼻咽癌组织中阳性表达率为68.5%,MACC1蛋白的表达与鼻咽癌的T分期、淋巴结转移和临床分期有关(P<0.05)。Kaplan-Meier生存曲线显示MACC1表达阳性的鼻咽癌患者5年总生存率(45.9%)明显低于MACC1表达阴性患者(73.7%)(P<0.05),Cox多因素分析显示MACC1蛋白是影响鼻咽癌预后的独立危险因素(P<0.05)。结论:MACC1蛋白在鼻咽癌中的高表达与鼻咽癌的浸润和转移密切相关,是鼻咽癌独立预后危险因素,有望成为鼻咽癌基因治疗的新靶点。

Objective To explore the expression of Metastasis-associated in colon cancer-1（MACC1） in patients with nasopharyngeal carcinoma（NPC）, and its relationship with clinical pathologic characteristics and prognosis Methods The expression of MACC1 was detected in 130 cases of NPC and the relationship among the MACC1 expressions, clinical pathologic characteristics and prognosis of NPC was analyzed. Results Positive expression rate of MACC1 was 68.5% in the NPC and MACC1 expression was associated with advanced T stages,lymph node metastasis and advanced clinical stages of NPC（P〈0.05）. The results of Kaplan-Meier survival analysis showed that the five year overall survival rate in patients with positive expressions of MACC1（45.9%）was significantly lower than that of those with negative expressions（73.7%） and the difference was statistically significant（P〈0.05）, Cox multi-factor analysis results showed that MACC1 expression was an independent prognostic factor for NPC（P = 0.004）. Conclusion MACC1 abnormal expression is closely related to the invasion and metastasis of NPC and it is expected to become a new target for gene therapy of NPC.