改良OCT检测法研究屈光参差性弱视儿童视网膜神经纤维层厚度

Investigation of retinal nerve fiber layer thickness in anisometropic amblyopic children with littmannadjusted OCT Examination

目的：利用改良OCT检测法研究屈光参差弱视儿童视网膜神经纤维层（RNFL）厚度。方法：随机选择未接受弱视治疗的4～14岁屈光参差性弱视儿童30例,取弱视眼为弱视组,非弱视眼为非弱视组;随机选取相同年龄50例正视儿童右眼作为正常对照组。利用光学相干断层扫描（OCT）测量患者视盘周围视网膜神经纤维层厚度,将所得三组数据利用Littmann公式修正,分别进行两两比较。结果：未校正和校正后三组间各部位RNFL厚度两两比较均无显著差异（P〉0.05）;校正前颞侧、颞下、鼻侧、鼻下RNFL厚度与眼轴有显著相关（P〈0.05）,而校正后仅颞侧及鼻下RNFL厚度与眼轴有显著相关（P〈0.05）。结论：屈光参差性弱视儿童弱视眼RNFL厚度并无显著变化,对RNFL厚度的研究需要消除眼轴长度形成的测量误差。

Objective To investigate the retinal nerve fiber layer（RNFL） thickness of anisometropic amblyopic children with Littmann-adjusted OCT examination method. Methods A total of 30 anisometropic amblyopic subjects（4 to 14 years old） without treatment were enrolled, whose amlyopic eyes were amlyopic eye group and fellow eyes were fellow eye group. Also 50 emmetropic children′s right eyes were enrolled into normal group. Retinal nerve fiber layer thickness were obtained with optical coherence tomography（OCT）, then were adjusted by Littmann formula. Each group was compared with other two groups specificly. Results Amblyopic eye group had no significant difference with other groups in each regions of RNFL（ P〉0. 05）, both before and after Littmann-adjusted. The RNFL of amblyopic group group in T 、 TI 、 NI 、 N regions had significant correlation with eye axis length before adjust（P〈0.05）, while only T and NI had significant correlation after adjust（P〈0.05）. Conclusions The RNFL thickness of anisometropic amblyopic eyes had no significant difference with fellow eye and normal eye. Every research of RNFL thickness must consider the measurement error induced by eye axis length.