在成年人群中补体C3与单纯性脂肪肝和脂肪性肝炎的关联

Complement C3 and simple fatty liver disease and nonalcoholic steatohepatitis in an adult population

目的探讨补体C3与非酒精性脂肪肝（单纯性脂肪肝和脂肪性肝炎）检出率之间的关联。 方法对天津医科大学总医院健康管理中心的2 799名健康体检者，采用多因素logistic回归模型评估补体C3四分位浓度与单纯性脂肪肝和脂肪性肝炎检出率之间的关联。 结果单纯性脂肪肝和脂肪性肝炎的检出率分别为31.9％和11.0%。在调整混杂因素后，C3水平四分位组从低到高，单纯性脂肪肝和脂肪性肝炎的OR（95%CI）分别为：单纯性脂肪肝，1.00（参考组）、2.15（1.55, 3.01），3.28（2.35, 4.6）和4.31（3.11，6.02）（P〈0.000 1）；脂肪性肝炎，1.00（参考组）、4.54（1.68，15.91），7.81（3.02，26.67）和14.91（5.94, 50.14）（P〈0.000 1）。 结论在成年人群中，血清C3水平与单纯性脂肪肝和脂肪性肝炎独立相关。

Objective To explore the association between complement C3 and the prevalence of simple fatty liver disease and nonalcoholic steatohepatitis. Methods A total of 2 799 health check-up participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Serum C3 levels were measured using immunoturbidimetry method and simple fatty liver disease and nonalcoholic steatohepatitis were diagnosed by liver uhrasonography and serum alanine aminotransferase concentration. Multiple logistic regression analysis was used to examine the association between quartiles of serum C3 levels and the prevalence of simple fatty liver disease and nonalcoholic steatohepatitis. Results After adjusting for covariates, the odds ratios （95% confidence interval） of simple fatty liver disease and nonalcoholic steatohepatitis for increasing quartiles of C3 were： 1.00 （reference）, 2.15 （1.55, 3.01）, 3.28 （2.35, 4.6） and 4.31 （3.11, 6.02）; and 1.00 （reference）, 4.54 （1.68, 15.91）, 7.81 （3.02, 26.67） and 14.91 （5.94, 50.14） （both P for trend〈0.000 1）, respectively. Conclusions The study found that the elevated C3 levels were significantly associated with the prevalence of simple fatty liver disease and nonalcoholic steatohepatitis. Further study is needed to clarify whether C3 has a predictive value for the occurrence of nonalcoholic fatty liver disease.