茯苓薏仁粉对痰湿质血脂异常影响的人群干预研究

Effect of India buead and coix seed powder on phlegm-dampness constitution dyslipidemia in population studies

目的探讨茯苓薏仁粉对痰湿质人群血脂异常的影响。方法运用随机对照人体试验设计，采用随机数字表的方法和随机数余数分组法将研究对象分为干预组和对照组，每组60例，年龄18~ 65岁，干预组男性21例，女性39例，对照组男性23例，女性37例，共计120例。自身对照比较用配对样本t检验，组间对照比较用独立样本t检验。计数资料用频数进行统计描述，用χ2检验。P〈0.05为差异有统计学意义。由SPSS18.0统计软件完成。在不改变原有日常生活方式的前提下，干预组服用茯苓薏仁粉90 d，通过自身和组间比较，分别观察总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平变化趋势及程度。同时，依据功效判定标准分别对TC、TG、HDL-C指标水平变化进行判定，并计算各指标有效率及总有效率。结果干预后，干预组TC降低8.9%、TG降低21.4%、LDL-C降低27.2%，HDL-C上升幅度为0.13 mmol/L。干预前后TC、TG、HDL-C和LDL-C比较差异有统计学意义（均P〈0.05）。干预组TC有效25例，无效35例，有效率41.7%，TG有效53例，无效7例，有效率88.3%，HDL-C有效26例，无效34例，有效率43.3%，总有效率57.8%。对照组TC、TG、HDL-C有效率均为0%。干预组TC、TG、HDL-C有效率均高于对照组。结论干预后，干预组的人群TC、TG、HDL-C、LDL-C指标均呈现出明显改善，茯苓薏仁粉对血脂异常痰湿质人群具有改善血脂的作用。

Objective To explore the anomalous effects of India buead and coix seed powder on phlegm-dampness constitution dyslipidemia through population-based intervention studies. Methods According to the experimental results of the model group with dyslipidemia, the phlegm-dampness population meeting the inclusion criteria were chosen as the samples for the randomized controlled trial, who were divided into test meal （21 males and 39 females） and blank control （23 males and 37 females） groups with 60 cases in each, aged 18 to 65 y and the total of 120 cases completed the study. Statistical analyses were performed with SPSS 18.0 statistical software. The self comparison wass conducted by the method of paired-sample t test and the comparison between groups was conducted by using independent sample t test. The categorical statistics were described as frequency and compared through E2 test, P〈0.05 was considered as statistically significant. Without changing the original way of life, the meal group having taken the India buead and coix seed powder was compared independently and with the control group for TC, TG, HDL-C and LDL-C to detect the trends and degrees of the level changes. Meanwhile, according to efficacy tests and standards, the changes in the level of TC, TG and HDL-C have been evaluated and the efficiency and total effective rates of all the variables have been calculated. Results After the intervention, there was a declining tendency in each variable, 8.9% in TC, 21.4% in TG, and 27.2% in LDL-C, except for an increase of 0.13 mmol/L in HDL. There were significant differences in the variables before and after the intervention （/9〈0.05 in each）. As for the test meal group after the intervention, the effectiveness of TC has been obtained in 25 cases and inefficacy in 35 cases, with efficiency of 41.7%; the effectiveness of TG has been shown in 53 cases and inefficacy in 7 cases, with efficiency of 88.3%; the effectiveness of HDL-C has been gained in 26 cases and inefficacy in 34 cases, with efficiency of 43.3%; and the total effective rate was 57.8%. Conclusions There are significant changes and improvements in TC, TG, HDL-C and LDL-C in the test meal group after the intervention with the powder, which demonstrate that the powder is effective in the reduction of TG for animals with dyslipidemia and populations with phlegm-dampness constitution.