结直肠癌肝转移微创射频消融术远期疗效影像评估

Analysis of Prognostic Factors of Radiofrequency Ablation for Colorectal Liver Metastases

目的:探讨射频消融对结直肠癌肝转移患者的远期疗效影像评估。方法:本研究回顾性分析2010年6月至2015年10月在浙江大学医学院附属邵逸夫医院接受RFA治疗的CRLM患者临床及影像资料。对所有患者射频后生存期(射频OS)及无进展生存期(PFS)运用SPSS22.0统计分析软件,通过KaplainMeier方法描绘患者生存曲线,进行单因素分析筛选;并对单因素筛选后有统计学意义的指标采用Cox比例风险模型进行多因素分析。结果:影响射频OS结局的因素是肝脏肿瘤最大直径、肝脏病灶数目、RFA术后1个月肿瘤灭活情况。影响PFS结局的因素为肝脏肿瘤最大直径、RFA术后1个月肿瘤灭活情况。结论:结直肠癌肝转移患者通过射频消融治疗后可获得较好的远期生存,特别是针对直径≤3cm、单发的病灶来说是一种安全有效的治疗手段。

Purpose： To investigate the prognostic factors of radiofrequency ablation （RFA） for the treatment of colorectal liver metastases（CRLM）. Methods： This study was carried out in the Sir Run Run Shaw Hospital affiliated to School of Medicine, Zhejiang University from June 1, 2010 to October 25, 2015. A total of 87 CRLM cases treated by RFA were selected. Potential prognostic factors were analyzed by Kaplan-Meier model, Log-rank test of univariate analysis and Cox regression model of multivariate analysis. Results： The OS after RFA was correlated with tumor counts, diameter and successive ablation of 1 month after RFA. Cox multivariate analysis indicated that PFS was correlated with tumor diameter and successive ablation of 1 month after RFA. Conclusion： RFA is a safe and effective therapeutic option for colorectal liver metastases, especially for those with diameter≤3cm and solitary tumor.