扶正减毒抗癌方防治非小细胞肺癌放疗所致急性肺损伤的临床研究

Clinical Study of Fuzheng Jiedu Kangai Decoction in the Prevention and Treatment of Acute Lung Injury Induced by Radiation Pneumonia of Non-small Cell Lung Cancer

目的研究四川省名医刁本恕创制的扶正减毒抗癌方对非小细胞肺癌放射治疗所致急性肺损伤的防治作用。方法纳入合格患者60例,随机分为对照组(常规放疗)30例及治疗组(常规放疗联合扶正减毒抗癌方)30例,均治疗20日。结果治疗组30例对照组28例完成实验。治疗后1月2组放射性肺炎发生率无显著差异,治疗后3月治疗组放射性肺炎发生率10%,低于对照组32.1%(P<0.05);治疗后1月治疗组咳嗽、咯痰、疲劳乏力、口干咽燥四项证候积分低于对照组,治疗后3月治疗组咳嗽、咯痰、疲劳乏力、胸闷气短、口干咽燥五项证候积分低于对照组(P<0.05);体力状态方面治疗后1月2组Karnofsky积分无统计学差异,而治疗后3月治疗组Karnofsky积分高于对照组(P<0.05);1年生存率治疗组33.3%,高于对照组10.7%(P<0.05),2年生存率未发现统计学差异。结论该扶正解毒抗癌方能减轻非小细胞肺癌放疗所致急性肺损伤,缓解相关临床症状,改善患者体力,提高1年生存率。

Objective To observe the effect of Fuzheng Jiedu Kangai decoction in the prevention and treatment of acute lung injury in-duced by radiation pneumonia of non-small cell lung cancer（NSCLC） after radiotherapy. Methods 60 eligibles were randomly divided into two groups. 30 patients in the treatment group were treated with Fuzheng Jiedu Kangai decoction and radiation therapy for 4weeks. 30 patients in the control group were treated with radiation therapy alone for the same course of treatment. Results 30 cases in the treatment group and 28 cases in the control group completed the experiment. After one month of treatment, there was no significant difference in the incidence of radiation pneumonia between the two groups. After three months of treatment, the incidence of radiation pneumonia of the treatment group was 10% which was lower than 32.1% of the control group（P〈0.05）. After one month of treatment,cough, expectoration, fatigue, dry mouth and throat four syndrome score of the treatment group were lower than those of the control group. After 3 months of treatment, cough, expectoration, fatigue, shortness of breath, dry mouth and throat five syndrome score of the treatment group were lower than those of the control group（P〈0.05）. After one month of treatment, there was no significant difference between the two groups in the physical condition on Karnofsky score. After 3 months of treatment, Karnofsky score of the treatment group was higher than that of the control group（P〈0.05）. The the one year survival rate of the treatment group was 33.3% which was higher than 10.7% of the control group（P〈0.05）. There was no significant difference on two year survival rate. Conclusion Fuzheng Jiedu Kangai decoction can reduce acute lung injury induced by radiation pneumonia of non-small cell lung cancer, alleviated clinical symptoms, and improved the physical strength and the one year survival rate.