儿泻停联合益生菌治疗婴儿抗生素相关性腹泻100例

Erxieting combined with Probiotics in the Treatment of Antibiotic-associated Acute Diarrhea in Infants for 100 Cases

目的探讨使用中成药物儿泻停颗粒联合微生态制剂较单独微生态制剂治疗抗生素相关性急性单纯性腹泻的疗效。方法选取2015年1月—2015年11月安徽省儿童医院呼吸病区诊断为呼吸道感染患儿160例,入院前患儿无腹泻,大便常规正常,住院使用抗生素24小时后出现腹泻,多为稀便。将患儿随机分为2组,治疗组100例,对照组60例。两组患儿均以静脉给予抗生素及中药喜炎平注射液治疗。治疗组口服双歧杆菌四联活菌片同时加儿泻停颗粒;对照组单纯口服双歧杆菌四联活菌片。治疗后第(3±1)天评价疗效结果。结果治疗组治愈率为39.0%,有效率为61.0%,对照组治愈率为21.7%,有效率为43.3%,治疗组治愈率、有效率均高于对照组,差异有统计学意义(P<0.05)。结论与单独使用益生菌治疗抗生素相关性单纯性腹泻相比,儿泻停联合益生菌可以更有效缓解并消除抗生素本身所导致的婴儿急性单纯性腹泻。

Objective To investigate the therapeutic effect of combined use of the Erxieting Chinese medicine and probiotics in the treatment of antibiotic-associated acute diarrhea in infants. Methods In the pulmonary diseases ward of Anhui province children ＇s hospital, between the period of January 2015 and November 2015, 160 children were diagnosed with respiratory tract infection. They had no previous symptoms of diarrhoea before admission in hospital. Their defecation was normal. After 24 hours of administration of the antibiotics in the hospital, the symptoms of diarrhea appeared in them. For investigations, the children were randomly divided into two groups, one being the treatment group with 100 patients and the other group being the control group of 60 patients. Both groups were administered intravenous antibiotics and Xiyanping injection. Four tablets of Bifidobacterium（Probiotics） and Erxieting were administered at once to the treatment group. The control group was only given four Bifidobacterium Probiotics oral tablets. After（3 ±1） days of the treatment, the results were evaluated. Results According to the results, the cure rate and the effective rate of the treatment group was 39% and 61%, respectively. The cure rate and the effective rate of the control group was 21.7 % and 43.3%, respectively. Both the cure rate and the effective rate of the treatment group was significantly higher than that of the control group, re-spectively, and there was statistically significant difference（ P 〈0.05）. Conclusion The use of Erxieting Chinese medicine combined with probiotics is a more effective way to mitigate and eliminate acute diarrhea caused by antibiotics themselves in infants as com-pared to the separate use of probiotics.