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5β-雄甾-3-烯-17-酮的合成研究

Synthesis of 5β-androst-3-en-17-one
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摘要 目的研究重要甾类药物中间体5β-雄甾-3-烯-17-酮的合成。方法以去氢表雄酮为原料,经Oppenauer氧化、Clemmensen还原反应得到5β-雄甾-3-烯-17-酮,重点研究了还原反应中金属、酸、溶剂等反应条件对反应速率及反应产物中5β-构型比例的影响。结果成功获得5β-雄甾-3-烯-17-酮,总产率为72.1%。结论该工艺简单,反应快,产率高,环境友好。 Objective To synthesize 5β-androstan-3-en-17-one as an important intermediate for steroidal drugs. Methods 5β-androstan-3-en-17-one was synthesized from dehydroepiandrosterone via Oppenauer oxidation and Clemmensen reduction. The effects of the metal, acid, and the solvent on the reduction product were de- termined. Results 5β-androstan-3-en-17-one was obtained with an overall yield of 72.1%. Conclusion The method is quick and convenient and environment friendly with high yield.
作者 叶鹏 杨波 郭晓红 刘秀娟 柯贤炳
机构地区 武汉大学人民医院药学部 武汉生物工程学院
出处 《中南药学》 CAS 2016年第9期957-959,共3页 Central South Pharmacy
基金 武汉市高新技术产业科技创新团队计划项目(No.2015071704021617) 国家自然科学基金资助项目(No.21102109)
关键词 去氢表雄酮 5β-雄甾-3-烯-17-酮 Oppenauer氧化 Clemmensen还原 合成 dehydroepiandrosterone 5β-androstan-3-ene-17-one Oppenauer oxidation Clemmensen reduc-tion synthesis
分类号 R914 [医药卫生—药物化学]
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参考文献12

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中南药学
2016年 第9期

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