1Pachecn-Alvarez D, Sol a rzano-Vargas RS. Del R i o AL. Biotin in metabolism and its relationship to human disease[J]. Arch Med Res, 2002,33 (5) : 439-447.
2Rodriguez-Melendez R, Lewis B, McMahon RJ, el al. Diaminobiotin and desthiobiotin have biotin-like activities in Jurkat cells [J]. J Nutr,2003, 133:1259-1264.
3Pacheco-Alvarez D. Paradoxical regulation of biotin utilization in brain and liver and implications for inherited multiple carboxylase deficiency[J].J Biol Chem, 2004,279(50) : 52312-52318.
4Solorzano-Vargas RS, Pacheco-Alvarez D, Leon-Del-Rio A. Holocarboxylase synthetase is an obligate participant in biotin- medialed regulation of its own expression and of biolin-dependent carboxylases mRNA levels in human cells [J ]. Proc Natl Acad Sci USA, 2002,99 : 5325-5330.
5Wiedmann S, Eudy JD. Zempleni J. Biotin supplementation causes increased expression of genes encoding interferon-γ . inlerleukin-1 β, anti 3-methylerottmyl-CoA carboxylase, and causes decreased expression of the gene encoding inlerleukin-4 in human peripheral blood mononuclear cells [J ]. J Nulr, 2003, 133:716-719.
6Mock DM. Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of bintin deficiency on gene expression and enzyme activities in mouse dam and fetus[J]. J Nutr Biochem, 2005,16 ( 7 ) : 435 -437.
7Le o n-Del-R i o A. Biotin-dependent regulation of gene expression in human cells[ J ]. J Nutr Biochem, 2005,16( 7): 432-434.
8Manthey KC, Griffin JB,Zempleni J. Biotin supply affects expression of biotin transporters, biotinylalion of carboxylases, and metabolism of interleukin-2 in Jurkal cells [J]. J Nutr, 2002. 132: 887-892.
9Rodriguez-Melendez R. Schwab LD, Zempleni J. Jurkat cells respond to biotin deficiency with increased nuclear translocation of NF-kappaB, mediating cell survival [J]. Int J Vitam Nutr Res, 2004,74( 3 ) :209-216.
10Zempleni J, Chew YC, Hassan YI, et al. Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met? [J]. Nutr Rev,2008,66 (S1) :46-48.