眼底自发荧光在急性后极部多发性鳞状色素上皮病变不同阶段的特征分析

Characteristics of fundus autofluorescence imaging in different stages of acute posterior multifocal placoid pigment epitheliopathy

目的探讨眼底自发荧光在急性后极部多发性鳞状色素上皮病变(acute posterior multifocal placoid pigment epitheliopathy,APMPPE)中的影像学特征。方法对21眼急性期和18眼恢复期APMPPE患者行眼底自发荧光检查,对比眼底彩色照像及眼底荧光血管造影结果,观察不同病变阶段的影像学特征,分析该病的发展转归。结果急性期眼底自发荧光可见与眼底彩色照像及眼底荧光血管造影一致的高自发荧光区,高荧光边缘可见一低荧光区域。部分眼底彩色照象及眼底荧光血管造影已显示的病灶,在自发荧光成像上尚未显现。恢复期患者眼底自发荧光可见与眼底彩色照像及眼底荧光血管造影相一致的完全低荧光区,如尚存部分未完全死亡的视网膜色素上皮细胞,则在部分区域可见强荧光。结论 APMPPE患者可根据自发荧光的强弱判断病变阶段、病变进程情况,评估视网膜色素上皮细胞的功能。

Objective To investigate the characteristics of fundus autofluorescence imaging in different stages of acute posterior multifocal placoid pigment epitheliopathy （APMPPE）. Methods Twenty-three cases （ 39 eyes） with different stages of APMPPE underwent flmdus autofluorescence examination, compared with the color fundus photography and fundus fiuorescein angiography, imaging features was observed in different stages of disease, and the development of disease was analyzed. Results Hyper-autofluorescence area with a hypo-autofluorescence edge could be observed in acute APMPPE patients. Some lesions, which color photography and fluorescein angiography had been displayed, were not yet appeared in autofluorescence imaging. Patients in convalescent stage, hypo-autofluorescence were visible consistent with fundus color photo and fluorescence imaging, in the remaining part where retinal pigment epithelial cells existed,and the region showed hyper-autofluorescence. Conclusion The stage and course of APMPPE can be determined according to the strength of the autofluorescence and retinal pigment epithelial cell function can be assessed.