骨关节炎中的炎性因子与骨关节严重程度相关性分析

Correlation Analysis of Inflammatory Cytokines in the Patients with Different Degrees of Osteoarthritis

本研究旨在探索骨关节炎患者体内炎性因子IL-4、s IL-4R、b FGF与病情程度的相关性。选取骨关节炎患者65例,根据ISOA评分对其进行严重程度分级后,对其血清及关节液中的IL-4、s IL-4R和b FGF进行检测,分析各指标与患者病情严重程度的相关性。结果发现,观察组血清和关节液中的s IL-4R、b FGF的含量均明显高于对照组,差异有统计学意义。而IL-4在不同组别及观察组不同严重程度患者血清及关节液中均无明显差异(p>0.05);在不同程度骨关节炎患者体内s IL-4R、b FGF与ISOA评分值存在线性相关关系,差异有统计学意义。由此可认为,患者血清及关节液中s IL-4R、b FGF两项指标含量与关节炎严重程度相关,应该引起临床医师的足够重视,并采取相应的治疗措施。

The aim of this study was to explore the correlation between the inflammatory cytokines （IL-4, slL-4R, bFGF） and the patients＇ condition in the patients with different degrees of osteoarthritis. Sixty-five patients with osteoarthritis were enrolled in this study, dividing into different groups according to their ISOA scores and detecting the IL-4, slL-4R and bFGF in serum and synovial fluid, analyzing the correlation among them. In the results we found that the content of slL-4R and bFGF in serum and synovial fluid of observer group were significantly higher than that in the control group. But the IL-4 in serum or synovial fluid were not significantly different between the different groups, and the same result was found in the patients of observer group with different severity ofosteoarthritis （P〉0.05）. A linear correlation between slL-4R, bFGF and ISOA scores was found in the patients with different degrees of osteoarthritis. In conclusion, there is a correlation between the inflammato- ry cytokines （slL-4R and bFGF） in serum and synovial fluid and the severity of osteoarthritis, so clinicians should pay more attention and take appropriate therapeutic measures.