云南贯众化合物2对猪蛔虫驱除作用效果观察

Efficacy of compound 2 from Cyrtomium yunnaense on Ascaris suum in vivo

考察云南贯众化合物2对猪蛔虫驱除作用。以感染虫卵量约为6×105个/头的自然感染蛔虫病猪作为试验动物,试验过程中每天观察其临床表现,并于感染后2个月对粪便进行蛔虫卵检查和记数,60 d后粪检虫数达7 000个/g则可作为猪蛔虫病模型的供试动物;云南贯众化合物2作为供试药物。结果表明,云南贯众化合物2驱除猪蛔虫作用效果明显,且具有吸收分布快、消除缓慢和生物利用率高等特点,其驱虫效果确实可靠。

To study the efficacy of compound 2 from Cyrtomium yunnaense on Ascaris suum in vivo, pigs naturally infected with Ascaris suum were daily observed on its clinical manifestations, and Ascaris eggs were counted after 2 months, when the fecal worm number was up to 7 000 EPG, the pigs were administrated with compound 2 from Cyrtomium yunnaense [Kaempferol-3- aL-（4-O- Acetyl） l-rhamnopyranoside-7-a-L- rhamnopyranoside]. The results showed that compound 2 from Cyrtomium yunnaense compound could effectively expel Ascaris suum with fast absorption, slow elimination and high bioavailability.