苦参凝胶治疗宫颈HPV感染患者的随机对照临床研究

Randomized controlled study: Sophora flavescens gel in treatment of cervical HPV infection

该文旨在评价苦参凝胶治疗宫颈人乳头瘤病毒(HPV)病毒感染患者的有效性。选取黑龙江中医药大学附属第一医院妇科门诊的120例宫颈HPV病毒感染患者,随机分为3组,即试验组(宫颈外涂苦参凝胶)、对照组(宫颈外涂重组人干扰素α-2b凝胶)、联合用药组(苦参凝胶联合重组人干扰素α-2b凝胶)。3组疗程均为3个月。观察治疗前后患者HPV病毒载量、不同分型病毒载量变化的情况。研究结果可为苦参凝胶的临床应用提供指导作用。

This study aimed to evaluate the efficacy of Sophora flavescens gel in treatment of cervical HPV infection. 120 patients with cervical HPV infections were selected from department of gynecology,the first affiliated hospital,Heilongjiang university of Chinese medicine. They were randomly divided into three groups： test group（ S. flavescens gel,40 cases）,control group（ human recombinant interferon α-2b gel,40 cases） and combined application group（ combination of the above two,40 cases）. The treatment course was three months in all three groups. Before and after treatment,the changes of HPV viral load and the changes of viral load for different HPV types were observed. The results could provide guidance for clinical application of S. flavescens gel.