摘要
We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close rela- tionship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the under- lying molecular mechanisms and functional/behavioural outcomes.
We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close rela- tionship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the under- lying molecular mechanisms and functional/behavioural outcomes.
基金
Research in the Swayne lab was supported by operating grants to LAS from the Natural Sciences and Engineering Research Council of Canada(NSERC Discovery Grant)
the Canadian Institutes of Health Research(CIHR Grant MOP142215)
The Scottish Rite Charitable Foundation of Canada and the University of Victoria Division of Medical Sciences
by infrastructure grants from the Canadian Foundation for Innovation(CFI)
the British Columbia Knowledge Development Fund(BCKDF)
supported by a Michael Smith Foundation for Health Research and British Columbia Schizophrenia Society Foundation Scholar Award
supported by a University of Victoria Fellowship Graduate Award
supported by a Vanier Canada Graduate Scholarship(NSERC)
