肿瘤深部热疗智能温控系统临床效果研究

Clinical effectiveness of an intelligent shell temperature control system in deep tumor hyperthermia

目的：探讨肿瘤深部热疗智能温控系统对胸部及腹部恶性肿瘤体表温度的监控效果。方法2015—2016年间将智能温控系统用于胸、腹部肿瘤热疗（实验组胸、腹部肿瘤分别为37、26例），将其和常规冷却水袋更换法（对照组胸、腹部肿瘤分别为37、25例）进行随机对比研究，观察两者在患者体表温度监控上的效果。结果实验组分别平均在热疗开始24.1、21.8 min时启动第1次冷却系统，平均启动次数均为2.5次；对照组在热疗开始平均33.1、33.8 min时患者自主提醒更换水袋，平均更换次数均为3.6次。第1次启动冷却系统和更换冷却水袋时胸组、腹组体表最高温度平均分别为38.5、39.3℃和39.1、40.4℃，胸部热疗组采用和未采用深部热疗智能温控系统分别有1例和4例出现≥Ⅱ度烫伤，腹组采用和未采用该系统分别出现0例和3出现≥Ⅱ度烫伤。结论深部热疗智能温控系统能比常规更换水袋冷却法提前发现患者体表高温区并进行冷却降温有效降低皮肤烫伤发生概率。

Objective To investigate the clinical effectiveness of an intelligent shell temperature control system in deep tumor hyperthermia for controlling the temperature in the outer shell of chest and abdominal malignancies. Methods From 2015 to 2016,a randomized comparative study was carried out in the intelligent temperature control system （ experimental group containing 37 patients with chest tumor and 26 patients with abdominal tumor ） and conventional cooling by replacement of water bags （ control group containing 37 patients with chest tumor and 25 patients with abdominal tumor） for chest and abdominal tumor hyperthermia. The effectiveness in controlling the outer shell temperature was compared between the two methods. Results In the experimental group, the first boot of the cooling system occurred at 24.1 and 21.8 minutes on average after the hyperthermia started and the average number of system boots was 2.5. In the control group, patients reminded to replace the water bag at 33.1 and 33.8 minutes on average after the hyperthermia started and the average number of replacements was 3.6. The highest outer shell temperature in patients with chest tumor and abdominal tumor averaged 38.5 and 39.1 ℃ at the first boot of the cooling system in the experimental group and 39.3 and 40.4 ℃ at the first replacement of the cooling water bag in the control group, respectively. The treatment with and without the intelligent temperature control system caused grade ≥Ⅱ empyrosis in 1 and 4 patients with chest tumor and in 0 and 3 patients with abdominal tumor, respectively. Conclusions In deep tumor hyperthermia, compared with the conventional cooling by replacement of water bags, the intelligent shell temperature control system can detect and cool the high.temperature zone in the outer shell at an earlier time, which effectively reduces the incidence of skin burn injury.