PET在粒子束治疗中路径及位置验证的应用

Application of position emission tomography in verification of beam path and position in charged particle radiation therapy

粒子束治疗是当今最精确的外照射手段之一，它们倒置的剂量沉积特点及射程末端高剂量布拉格峰区，能在给予肿瘤区高剂量的同时尽量避免周围组织的损伤。但同时，如果布拉格峰区位置的偏移，也将会造成严重的后果，因而对射束进行监测显得尤为重要。 PET引入重离子及质子治疗，对于确切了解粒子束的照射范围及位置提供了可能，进而有助于推进粒子治疗的精确化。本文就具体阐述目前PET在粒子束治疗中位置验证的应用状况。

Charged particle radiation is one of the most precise approaches for external radiation right now. With a characteristic inverted depth.dose profile and a high.dose Bragg peak at the end of the range, charged particle radiation therapy can deliver a high dose of radiation to tumor without damages in tissue around the tumor. However, a shift of Bragg peak would result in severe consequences. Therefore, it is extremely important to monitor the radiation beam. Application of position emission tomography （ PET） in proton and heavy.ion radiation therapy makes it possible to get accurate radiation range and position of the particle beam, which improves the treatment accuracy of charged particle therapy. This paper introduces the current application of PET in position verification of charge particle range radiation therapy.