中老年人慢性代谢性疾病相关代谢指标的研究

Study of the related metabolic indexes of chronic metabolic diseases in elderly people

目的探讨中老年人群中高血压、糖尿病与骨质疏松症相关代谢指标的变化。方法 选择2013年6月～2016年6月在广西壮族自治区第三人民医院就诊的中老年高血压、糖尿病与骨质疏松症患者各60例为研究对象,分别设为血压组、糖尿病组及骨质疏松组;另选50名健康中老年人为对照组。测定并比较各组受试者游离脂肪酸（FFA）、空腹血糖（FBG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）及25羟维生素D的水平。结果 高血压组及糖尿病组患者的血清FFA、FBG与HOMA-IR均高于对照组（P〈0.05或P〈0.01）,而FINS水平与对照组比较差异无统计学意义（P〉0.05）;骨质疏松组血清25羟维生素D水平显著低于对照组（P〈0.01）,而血清FFA、FBG、HOMA-IR及FINS水平与对照组比较差异无统计学意义（P〉0.05）。结论 在中老年人群中,高血压患者可能伴有FFA水平升高,而糖尿病患者则常伴有明显的胰岛素抵抗,骨质疏松患者常伴有25羟维生素D水平低下。因此检测这些指标对于高血压、糖尿病与骨质疏松症的早期诊断与及时干预具有重要意义。

Objective To study the changes of the related metabolic indexes in the patients with hypertension, diabetes mellitus and osteoporosis. Methods Sixty eider patients with hypertension, 60 patients with diabetes mellitus and 60 patients with osteoporosis from June 2013 to June 2016 in the Third People＇s Hospital of Guangxi Zhuang Autonomous Region were chosen as the research objectives, and they were set as the hypertension group, diabetes mellitus group, and osteoporosis group, respectively; and 50 cases health elder people were chosen as control group. The free fatty acids （FFA）, fasting blood glucose （FBG）, FINS, HOMA-IR and 25-hydroxy vitamin D of research objectives in each groups were detected and compared. Results The serum FFA, FBG and HOMA-IR level of the hypertension group and diabetes mellitus group were obviously higher than the controlled group （P 〈 0.05 or P 〈 0.01）, and the FINS level of the two groups had no statistical difference compared with the control group （P 〉 0.05）; the 25-hydroxy vitamin D level of the osteoporosis group was markedly lower than the control group （P 〈 0.05）, and the serum FFA, FBG, HOMA-IR and FINS of the osteoporosis group had no statistical difference compared with the control group （P 〉 0.05）. Conclusion The elderly patients with hypertension may be associated with elevated levels of free fatty acids, while the elderly patients with diabetes are often accompanied by obvious insulin resistance and osteoporosis in elderly patients often associated with low level of 25 hydroxyl vitamin D. Detection of these indicators is of great significance for the early diagnosis and timely intervention in the elderly patients with hypertension, diabetes and osteoporosis.