硫辛酸及胰岛素强化治疗对早发2型糖尿病胰岛功能的影响

The Effect of a-lipoicin and Early Intensive Insulin Treatment on the Function of Pancreatic Islet β-cells in the Patients with Newly-diagnosed Type 2 Diabetes Mellitus

目的探讨硫辛酸及胰岛素强化治疗对初发2型糖尿病胰岛功能的影响。方法采集60例初发的2型糖尿病患者,随机分成2组,对照组给予胰岛素强化治疗,实验组在胰岛素强化治疗的基础上,给予硫辛酸0.6 g溶于250 m L生理盐水中静脉滴注,根据血糖及时调整胰岛素剂量,4周为一疗程,治疗前后分别测定胰岛素分泌指数及胰岛素抵抗指数。结果与治疗前相比,2组胰岛素分泌指数明显增加,以实验组更为明显,2组胰岛素抵抗指数明显下降,同样实验组更为突出,且治疗组总有效率高于对照组(P=0.02)。结论硫辛酸联合胰岛素强化治疗初发2型糖尿病更能提高胰岛素敏感性,减轻胰岛素抵抗,更能促进胰腺B细胞功能的恢复。

Objective To assess the effect of a-lipoicin and intensive insulin therapy on the function of pancreatic islet β-cells in the patients with newly diagnosed type 2 diabetes. Methods 60 newly diagnosed T2 DM patients were divided into two groups, one group as control was given intensive insulin treatment,Based on this, The treatment group were added a-lipoicin 0.6g into Sodium chloride250 ml to intravenous drip, the dose of insulin were given based on blood sugar. The period of treatment is four weeks. Results After treatment, both groups,HOMA-β was increased. Compared with the before treatment, HOMA-IR remarkably lowered in both groups,and more significantly in treated group than in control group（P0.05）.And what,s more, the total effect rate was higher in treatment group than in the control group. Conclusions a-lipoicin and intensive insulin therapy can enhance insulin sensitivity, alleviate insulin resistance, and accelerate the recovery of the pancreatic B cell in newly- diagnosed type 2 diabetic patients.