心房颤动与慢性牙龈炎的相关性研究

Relationship Between Atrial Fibrillation and Chronic Gingivitis

目的探索心房颤动与慢性牙龈炎的相关性。方法选取2014-10—2015-12间在贵州医科大学附属医院心内科住院病人119例,分为房颤组、室上性心动过速组（对照组）,两组病例年龄、性别差异等基本特征相近。入院次日采集静脉血送生化室测定血清炎症介质Hs-CRP、IL-6,同时常规行心脏超声测量左心房内径（LAD）。应用SPSS17.0统计软件进行数据分析,计量资料组间及组内分别采用方差分析及配对t检验（两独立样本t检验）,方差不齐采用秩和检验分析,以P〈0.05为差异有统计学意义。结果房颤组血清Hs-CRP、IL-6、心房内径较对照组显著升高（P〈0.05）。69例房颤组病人中慢性牙龈炎患者发病率为71%;50例对照组患者慢性牙龈炎患者发病率为52%;房颤组患者中慢性牙龈炎的发病率与对照组慢性牙龈炎发病率差别有统计学意义。重度慢性牙龈炎（牙龈指数3级）患者血清炎症指标（Hs-CRP、IL-6）较轻度慢性牙龈炎（牙龈指数1级）及正常牙龈患者血清炎性指标升高较明显,数据以M（P25~P75）表示,秩和检验,P〈0.05,差异有统计学意义。结论重度慢性牙龈炎可引起血清Hs-CRP、IL-6升高,房颤与重度慢性牙龈炎有一定相关性。

Objective To investigate the correlation of gingivitis and atrial fibrillation（ AF）. Methods 119 gingivitis patients were enrolled from the Cardiovascular Department from October,2014 to December,2015. And they were divided into AF group. The clinical features of age and sex in two groups were similar. All enrolled patients had venous blood collection to detect serum Hs-CRP and IL-6 in biochemical laboratory of the hospital on the second hospital day. Left atrial diameter（ LAD） was measured by cardiac ultrasound in ultrasonic center. The data was analyzed by SPSS17. 0 statistical software,measurement data between groups and within groups were analyzed by variance analysis and paired t test（ two independent samples t-test）. When rank sum test was used,the difference was statistically significant,P〈 0. 05. Results Compared with control group,there was significant rise in level of serum Hs-CRP,IL-6 and LAD in atrial fibrillation group（ P〈 0. 05）. Among 69 AF patients,the incidence rate is 71%; and among 50 cases in the control group,the incidence rate is 52%. The difference is statistically significant between the incidence of atrial fibrillation group compared with gingivitis patients in control group. The serum inflammation factors（ Hs-CRP,IL-6） in intense gingivitis patients（ GI 3 Degree） are higher than mild gingivitis（ GI 1 Degree） and health gingival. There is a significant difference between two groups. The data is expressed by M（ P25- P75）.Conclusion Serum inflammatory cytokine levels significantly rise in patients with intense gingivitis. There is a certain correlation between the atrial fibrillation and gingivitis.