不同去势方式治疗晚期前列腺癌的现状及进展

Current status and progress of different methods of castration for treatment of advanced prostate cancer

前列腺癌是老年男性常见的疾病之一,发现时多为晚期。对于晚期前列腺癌而言,其首选的治疗手段为内分泌治疗,其中以最大雄激素阻断疗法即去势+抗雄激素治疗最为常用,有关去势方式又可分为手术去势和药物去势。目前临床上对于手术或药物去势的选择虽有大量文献进行比较分析,但尚无统一的选择标准。本文就晚期前列腺癌内分泌治疗中不同去势方式的选择做一综述。

Prostate cancer is one of the common diseases in the elderly.It is found mostly late.Endocrine therapy is the first choice for the treatment of advanced prostate cancer,and maximum androgen blockade therapy,namely as castration plus anti-androgen treatment is most commonly used at present.The ways of castration can be classified as surgical castration and medical castration.There is still no uniform standard,though a large amount of literature has analyzed and compared between these two methods.In this paper,the selection of different methods of castration for the treatment of advanced prostate cancer will be reviewed.