间充质干细胞上TNF-α受体在脓毒症急性肾损伤中的作用

The therapeutic effect of tumor necrosis factor alpha receptors on mesenchymal stem cells in acute kidney injury induced by endotoxin

脓毒症急性肾损伤的发病率逐年上升,死亡率也逐年提高,寻求一种有效的治疗方法是目前的当务之急.间充质干细胞是一种多能干细胞,前期已有大量的实验证明,间充质干细胞用于治疗脓毒症急性肾损伤是有效的,并且也有相关证据表明TNF-α刺激后,可以加强间充质干细胞的这一作用.众所周知,TNF-α主要是与其相关受体结合以后方可发挥作用,MSC上同时存在TNFR1和TNFR2这两种受体,究竟是何种受体在治疗脓毒症急性肾损伤中发挥作用,就此作一综述.

The incidence and mortality of sepsis induced acute kidney injury increased year by year, so seek an effective therapeutic method is the top priority currently.A large number of previous experiments have shown that multipotent mesenchymal stem cells had an protective effect on the treatment of sepsis induced acute kidney injury and TNF alpha can strength this protective effect.Proverbially,the TNF alpha can play a role in the acute renal failure mainly after associated with its receptors,and there are two kinds of receptors on mesenchymal stem cells such as tumor necrosis factor alpha receptor 1 and tumor necrosis factor alpha receptor 2.This article will give a summarization about which receptor plays a key role in the treatment of acute kidney injury induced by endotoxin.