盐酸阿替卡因的平衡溶解度和油水分配系数的测定

Determination of equilibrium solubility and oil/water partition coefficient of articaine hydrochloride

目的:测定盐酸阿替卡因在不同介质中的平衡溶解度和在正辛醇-水和正辛醇-缓冲液体系中表观油水分配系数并研究pH对其的影响.方法:采用HPLC法测定盐酸阿替卡因的浓度,用摇瓶法测定盐酸阿替卡因的表观油水分配系数.结果:盐酸阿替卡因易溶于生理盐水、蒸馏水和系列不同pH的磷酸盐缓冲液.盐酸阿替卡因在正辛醇-水中的分配系数P为0.31(lgP=-0.51).结论:盐酸阿替卡因为溶解度大的亲水性药物.

Aim：To determine the equilibrium solubility of articaine hydrochloride in various media, its oil /water partition coefficients in n-octanol-water/buffer solution systems,and to investigate the effects of pH on the above parameters.Methods：High performance liquid chromatography was used to determine the concentration of articaine hydrochloride;the partition coefficients of articaine hydrochloride in n-octanol-water/buffer solution systems were determined by shaking flask method.Results：Articaine hydrochloride is freely soluble in normal saline,distilled water and buffer solutions with various pH values.The partition coefficients of articaine hydrochloride was 0.31 （lgP =-0.51 ）in n-octanol-water system.Conclusion：Articaine hydrochloride is a drug with great solubility and hydrophilicity.