脑电图在路易体痴呆和阿尔茨海默病鉴别中作用的研究

The EEG as a diagnostic tool in distinguishing between dementia with Lewy bodies and Alzheimer's disease

目的此研究的目的是探讨总计脑电图(GTE)得分用于区别诊断路易体痴呆(DLB)和阿尔茨海默病(AD)的作用。方法根据GTE得分对30例DLB患者和52例AD患者的脑电图(EEG)进行了直观的评估。结果 DLB患者平均得分显著高于AD患者,得分比为9:4.DLB患者以6.5的GTE截止得分区别于AD患者,其灵敏度为80%,特异性为78%。GTE和DLB之间的关联独立于年龄、性别、简易精神状态检查和药物使用。额叶间歇节奏增量活性(FIRDA)在DLB患者和AD患者中分别为16.7%、1.9%。结论 EEG作为日常临床实践中区分DLB和AD的诊断工具应该发挥更加突出的作用。GTE得分法已被证明是适用于日常临床实践的可靠简单的评分法。定性EEG分析对于区别诊断DLB和AD帮助较大,并且有较高的灵敏度和特异性。

Objective To explore the effect of EEG total score（GTE） in differential diagnosis of dementia with Lemy bodies（DLE）and Alzheimer＇s disease（AD）. Method EEGs from 30 patients with DLB and 52 with AD were visually rated according to the GTE score. Results Patients with DLB had significantly higher median scores than patients with AD： 9 vs 4. Patients with DLB could be distinguished from those with AD at a GTE cut-off score of 6.5 with a sensitivity of 80% and a specificity of 78%. The association between GTE and DLB was independent of age, gender, Mini Mental State Examination and use of medication. Frontal intermittent rhythmic delta activity （FIRDA）was found in 16.7% of patients with DLB compared to 1.9% with AD. Conclusion The GTE score has proven to be a reliable and simple scoring method applicable to daily clinical practice. Qualitative EEG analysis can help to differentiate DLB from AD with good sensitivity and specificity.