老年血管性痴呆患者血清HIF-1α、VEGF的变化及相关性研究

Changes and relevance analysis of serum HIF-1α and VEGF in patients with elderly vascular dementia

目的研究老年人血管性痴呆(Va D)患者血清低氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)水平的变化。方法检测88例老年Va D患者和30例健康老年人血清HIF-1α、VEGF水平的含量,比较两组间血清HIF-1α、VEGF水平的差异;分析血清HIF-1α、VEGF水平与痴呆程度的关系。结果老年人Va D患者血清HIF-1α、VEGF水平较正常健康老年人明显增高(P<0.01)。不同痴呆程度的老年Va D患者血清HIF-1α、VEGF水平的比较差异没有统计学意义(P>0.05)。结论血清HIF-1α、VEGF水平与老年人Va D有密切相关。

Objective To detect the expressions of serum hypoxia-inducible factor-1α（HIF-1α） and vascular endothelial growth factor（VEGF） in patients with elderly vascular dementia. Method A total of 88 patients with senile vascular dementia and 30 healthy senile people were enrolled in the study. Serum HIF-1α and VEGF levels in patients with senile vascular dementia and healthy senile people were determined and analyzed.The relation between serum HIF-1α ,VEGF levels and degree of dementia was analyzed. Results Compared with healthy senile people,serum HIF-1α and VEGF levels in patients with senile vascular dementia increased significantly（P〈0.01）. The serum HIF-1α, VEGF levels were not significant differences in different degrees of vascular dementia（P〉0.05）. Conclusion The serum HIF-1α and VEGF levels is closely related to senile vascular dementia.