D-二聚体对晚期结直肠癌患者预后的影响

The prognosis of D-dimer level in advanced colorectal cancer patients

目的：探讨首次化疗前 D -二聚体水平对晚期结直肠癌患者预后的影响。方法：检测62例复发或转移性结直肠癌患者化疗前 D -二聚体水平，分析其与临床因素、化疗疗效、总生存期的相关性。结果：D -二聚体低水平组与高水平组在各临床因素间、化疗疗效间的比较均无统计学意义（P 〉0.05），多因素生存分析显示 CEA 水平、D -二聚体水平是总生存期的独立预后因素（HR =3.454，95% CI =1.151-10.369， P =0.027；HR =2.380，95% CI =1.082-5.253，P =0.031）。结论：D -二聚体水平可作为晚期结直肠癌患者总生存期的预后因素，但不足以预测化疗疗效。

Objective：To explore the prognosis of plasma D - dimer level before chemotherapy for the first time in advanced colorectal cancer patients. Methods：All 62 cases of recurrent or metastatic colorectal cancer patients were detected plasma D - dimer level before chemotherapy and were analyzed the correlation of D - dimer level with clinical factors,therapeutic effect and overall survival. Results：The comparisons among groups of clinical factors,therapeutic effect with high plasma D -dimer level than in patients with low level were not statistically significant（P 〉 0. 05）. CEA, D - dimer level were the independent prognostic factors in multivariate survival analysis（ HR = 3 . 454 ,95 % CI= 1. 151 - 10. 369,P = 0. 027;HR = 2. 380,95% CI = 1. 082 - 5. 253,P = 0. 031）. Conclusion：For advanced colorectal cancer patients,D - dimer level can be utilized as predictor of overall survival but not for therapeutic effect.