氧化低密度脂蛋白胆固醇及相关因素与高血压并发脑梗死的相关性分析

The Correlation Analysis among Oxidized Low Density Lipoprotein,Control of Risk Factors and Cerebral Infarction in Patients with Essential Hypertension

目的研究氧化低密度脂蛋白胆固醇(ox-LDL)水平及危险因素与高血压病并发脑梗死的相关性。方法分析91例高血压病病人的临床资料,比较并发与未并发脑梗死病人的血清ox-LDL水平,病人血糖、血脂等危险因素控制情况,采用Logistic回归分析ox-LDL水平及多重危险因素与高血压病人并发脑梗死之间的关系。结果与未并发脑梗死组比较,并发脑梗死组病人血清ox-LDL水平明显升高(16.78μg/d L±11.41μg/d L vs 35.42μg/d L±23.11μg/d L,P<0.01)。与无糖尿病或血脂异常病史病人比较,有相关病史者血糖、总胆固醇和低密度脂蛋白胆固醇的未达标率明显增高(P<0.05或P<0.01)。Logistic回归分析显示,ox-LDL、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇异常对高血压并发脑梗死的优势比分别为17.491、10.905和4.835(P<0.05或P<0.01)。结论血清ox-LDL水平升高及危险因素控制不良与高血压病并发脑梗死密切相关。

Objective To study the correlation analysis among oxidized low-density lipoprotein（ ox-LDL）,control of risk factors and cerebral infarction in patients with essential hypertension（ EH）. Methods The clinical data of 91 patients with EH were investigated. The changes of serum ox-LDL levels were compared between patients with cerebral infarction and non cerebral infarction. The control of risk factors,e. g,blood glucose and blood lipid were analyzed. Then the correlation among ox-LDL,multiple risk factors and cerebral infarction in patients with hypertension were analyzed by Logistic regression analysis. Results Compared with the non cerebral infarction group,the level of serum oxLDL was significantly increased in the cerebral infarction group（ 16. 78 μg / d L ± 11. 41 μg / d L vs 35. 42 μg / d L ± 23. 11 μg / d L,P〈0.01）. Compared with the no history of diabetes or dyslipidemia group,the non-compliance rate of blood glucose,cholesterol and low density lipoprotein test results were significantly increasedin the history group（P〈0. 05 or P〈0. 01）. The Logistic stepwise regression analysis confirmed that the odds ratios of ox-LDL,high density lipoprotein and low density lipoprotein for hypertension complicated with cerebral infarction were 17. 491,10. 905 and 4. 835,respectively（P〈0. 05 or P〈0. 01）. Conclusion Hypertension complicated with cerebral infarction is closely related to elevated serum ox-LDL levels and poor control of risk factors.