抗焦虑治疗良性阵发性位置性眩晕耳石复位治疗后残余头晕的疗效评估

Evaluation of anti anxiety treatment in residual dizziness after successful canalith repositioning procedure in benign paroxysmal positional vertigo

目的：探讨抗焦虑药物对良性阵发性位置性眩晕患者耳石复位治疗成功后残余头晕的疗效。方法纳入神经内科门诊及住院部的良性阵发性位置性眩晕患者耳石复位治疗成功后出现残余头晕68例，采用随机对照方法，随机分为抗焦虑组和对照组。抗焦虑组服用氟哌噻吨美利曲辛（黛力新）0．5 mg／10 mg，1次／d ＋甲磺酸倍他司汀6 mg，3次／d；对照组服用甲磺酸倍他司汀6 mg，3次／d。随访3个月，比较两组残余头晕持续时间及症状变化。患者均采用眩晕障碍量表评价治疗前后的症状变化。结果对照组残余头晕持续天数为（16．38±8．83）d，抗焦虑组为（10．13±5．10）d，与对照组相比天数明显缩短（t ＝3．440，P ＜0．05）。两组治疗后症状均好转，眩晕障碍量表评分均下降，对照组第1周、第2周、第3周分数分别为（26．60±13．54）分、（20．80±10．97）分、（6．27±5．88）分。抗焦虑组第1周、第2周、第3周分数分别为（23．10±11．02）分、（13．33±5．83）分、（0．67±2．50）分。治疗第1周，两组眩晕障碍量表得分差异无统计学意义（t ＝1．122，P ＞0．05）。第2周、第3周，抗焦虑组得分明显低于对照组，差异有统计学意义（t 分别为3．378、4．935，均 P ＜0．05）。治疗3周后，抗焦虑组患者在功能、情感、躯体分量表的分数均下降更显著（t ＝5．297、4．537、4．451，均 P ＜0．01）。结论黛力新能缩短良性阵发性位置性眩晕患者耳石复位成功后残余头晕的持续时间，并能减轻残余头晕程度。

Objective To study the effect of anti anxiety treatment in residual dizziness after successful canalith repositioning procedure in benign paroxysmal positional vertigo.Methods 68 cases of benign paroxysmal position vertigo patients with residual dizziness after successful canalith repositioning procedure were collected,who visit department of Neurology..They were randomly assigned to anti anxiety group and the control group according to randomized controlled method.Deanxit （0.5mg/10mg,1times/day）combined with betahistine mesilate tablets （6mg, 3 times/day）were taken by patients in the anti anxiety group;take betahistine mesilate tablets （6mg,3 times/day） were taken in the control group.Follow up 3 months,the duration of residual dizziness and the changes of symptoms between the two groups were compared.The symptoms of all patients were evaluated before and after treatment by dizziness handicap inventory.Results The duration of residual dizziness in the control group was （16.38 ±8.83）days, and that in the anti anxiety group was （10.13 ±5.10）days.The duration of residual dizziness in the anti anxiety group was significantly shorter than that in the control group （t =3.440,P 〈0.05）.In the control group,the scores of first week,s econd week and third week were （26.60 ±13.54）points,（20.80 ±10.97）points and （6.27 ±5.88）points.In the anti anxiety group,the scores of first week,second week and third week were （23.10 ±11.02）points,（13.33 ± 5.83）points and （0.67 ±2.50）points.There was not significant difference between the two groups （t =1.122,P 〉0.05）in the treatment of first week.In second week and third week,the scores of the anti anxiety group were lower than those of the control group,the differences were statistically significant （t =3.378,4.935,all P 〈0.05）.After 3 weeks of treatment,the scores of the anti anxiety group were significantly decreased in the functional,emotional and physical scores （t =5.297,4.537,4.451,all P 〈0.01 ）.Conclusion Deanxit can shorten residual dizziness duration of benign paroxysmal position vertigo patients after successful canalith repositioning procedure,and can reduce the degree of residual dizziness.