摘要
糖尿病并发抑郁症继发于糖尿病,是其自杀率最高的慢性并发症之一。目前,糖尿病并发抑郁症发病机制主要集中在下丘脑-垂体-肾上腺(HPA)轴功能异常和海马损伤两方面,2种机制互相影响,加重病情。除常规药物治疗外,心理干预和运动疗法都能改善糖尿病并发抑郁症患者的高血糖状况以及焦虑抑郁症状,多种方法联合具有更好的治疗效果。
Diabetes mellitus with depression is secondary to diabetes and is one of the chronic complications with the highest suicide rate. The pathogenesis of diabetes mellitus with depression mainly focuses on the hypothalamus-pituitary-adrenal axis（HPA axis） dysfunction and hippocampal damage. The two mechanisms worsen each other. In addition to conventional medical treatment, psychological intervention and exercise therapy help improve the hyperglycemic condition and symptoms of anxiety and depression in patients of diabetes mellitus with depression, and combination of various methods shows a better therapeutic effect.
作者
赵洪庆
凌佳
杜青
杨蕙
王宇红
ZHAO Hong-qing LING Jia DU Qing YANG Hui WANG Yu-hong(Training Bases of Hunan Key Laboratory of Chinese Materia Medica Powder and Innovative Drugs, Changsha 410208 First Hospital of Hunan University of Chinese Medicine, Changsha 410007)
出处
《中南药学》
CAS
2016年第10期1093-1097,共5页
Central South Pharmacy
基金
国家自然科学基金(No.81373578
No.81403379)
湖南中医药大学研究生创新课题(No.2015YF03)
关键词
糖尿病
抑郁症
下丘脑-垂体-肾上腺轴
海马损伤
diabetes mellitus
depression
hypothalamus-pituitary-adrenal axis
hippocampal damage
