氯胺酮炎症调节作用围术期应用进展

Ketamine： a review of its inflammatory regulation effect during perioperative period

背景 氯胺酮是临床上常用的麻醉药物,但其除了具有传统的麻醉作用外,近年来对氯胺酮抗炎作用的研究已经取得了较大进展. 目的 综述氯胺酮抗炎作用在临床应用中的研究进展,为其在围术期应用提供参考. 内容 氯胺酮有炎症调节作用,能够及时防止局部炎症反应的恶化,又避免了过度抑制促炎反应.氯胺酮是免疫调节剂,而非免疫抑制剂. 趋向 如何优化氯胺酮的给药剂量、方式和时机,是未来的研究趋势.

Background Ketamine is one of the anesthesia medications clinical commonly used.Besides its traditional anesthesia effect,other effects on the body are also important,such as anti-inflammatory,brain protection,anti-depression,preemptive analgesia and so on.The researches on its anti-inflammatory effect have made great progress in recent years.Objective To guide its anti-inflammatory treatment in perioperative patients and severe cases,this review analyzes its anti-inflammatory effect in clinical application.Content The article summarizes its general situation of the research progress about anti-inflammatory effects in clinical application,indicate that ketamine has obvious inflammatory regulation effect,that is to say ketamine is an immune modulators,rather than the immune inhibitors.Trend How to optimize the dose,methods and administration time of ketamine,it will be the major trend.