外泌体在间充质干细胞分化过程中的作用

The effect of exosomes in mesenchymal stem cell differentiation

背景:目前对于外泌体的了解主要在于它可由多种细胞分泌产生并传递各种物质而产生后续调控作用。目的:综述外泌体在间充质干细胞分化微环境中起到的作用,以便为进一步深入研究提供参考。方法:以"外泌体、间充质干细胞、细胞分化"为中文检索词,以"exosome、MSC differentiation"为英文检索词,在CNKI和Medline、Embase数据库检索2001年1月至2016年9月的相关文章,将所有文章进行初步筛选后,对保留的文章进一步详细分析、归纳并总结。结果与结论:外泌体是一种直径40-100 nm,可由多种类型细胞分泌,包含有功能性蛋白、基因产物等功能性物质的一种微型囊泡。作为相邻细胞之间传递功能物质的桥梁,外泌体在细胞间相互作用微环境中受到越来越广泛的重视。在间充质干细胞分化方面,主要通过外泌体miR NA的分泌对各相关通路产生调控作用。

BACKGROUND： Currently, what we know about exosomes is that it can be produced by a variety of cells and transfer a variety of materials, producing subsequent function of regulation. OBJECTIVE： To review the function of exosomes in mesenchymal stem cell differentiation, in order to provide reference for further in-depth study. METHODS： With the key words of ＂exosome, mesenchymal stem cell, differentiation＂ in Chinese and English, respectively, a computer-based search was performed for articles published in CNKI, Medline and Embase databases from January 2001 to September 2016. After the initial screening, the reserved articles were further detailed, summarized and concluded. RESULTS AND CONCLUSION： Exosomes are a kind of vesicles 40-100 nm in diameter, which can be secreted by a variety of cell types, containing functional products, such as functional protein, gene product, lipid and so on. As a bridge of adjacent cells transferring functional products, exosomes are becoming an issue of concern in the microenvironment for cell interaction. In the differentiation of mesenchymal stem cells, exosomes also play an indispensable role via pathway regulation.