益气活血通阳法治疗不稳定型心绞痛的疗效及对血清炎症因子的影响

Efficacy of Yiqi Huoxue Tongyang method for the treatment of unstable angina pectoris and its effect on serum inflammatory factors

目的观察益气活血通阳法治疗不稳定型心绞痛(UA)的疗效及对血清炎症因子的影响。方法将125例气虚血瘀型UA患者抽签分为观察组64例、对照组61例。对照组给予常规西医治疗,观察组在常规治疗的基础上加用益气活血通阳中药。2组均治疗1个月,观察2组疗效以及血清炎症因子(IL-6、hs-CRP、TNF-α、Hcy)变化。结果观察组总有效率为95.31%,对照组为80.33%,差异有统计学意义(P<0.05)。治疗后,2组IL-6、hs-CRP、TNF-α及Hcy均下降,差异有统计学意义(P<0.05);观察组各指标变化幅度均大于对照组,差异亦有统计学(P<0.05)。结论益气活血通阳法治疗UA疗效确切,有抑制炎症反应的作用。

Objective To observe the efficacy of Yiqi Huoxue Tongyang（ benefiting qi activating blood and smoothing yang） method for the treatment of unstable angina pectoris（ UA） and the effect on serum inflammatory factors. Methods 125 cases of UA patients of Qi deficiency and blood stagnation type were randomly divided into the observation group（ 64 cases） and the control group（ 61 cases）.The control group was given the regular western medicine,and the observation group was given Chinese herbal medicine for Yiqi Huoxue Tongyang on the basis of regular western medicine. After 1 month of treatment,the efficacy and the changes of serum inflammatory factors（ IL-6,hs-CRP,TNF-α and Hcy） were observed. Results The total effective rate of the treatment group was95. 31% while the control group was 80. 33%,the difference was statistically significant（ P〈0. 05）. After treatment,IL-6,hs-CRP,TNF-α and Hcy of both groups were significantly decreased and the difference was statistically significant（ P〈0. 05）; and the changes of all index of the observation group were much more significant than that of the control group with the difference statistically significant（ P〈0. 05）. Conclusion Yiqi Huoxue Tongyang method is definitely effective for the treatment of UA with the action of inhibiting the inflammatory reaction.