甲磺酸去铁胺对脑出血患者预后的影响

Effect of the deferoxamine mesylate on the prognosis of patients with intracerebral hemorrhage

目的：研究甲磺酸去铁胺对脑出血患者1年预后的影响。方法2013年2月至2014年5月，连续收集经满城区医院CT确诊、发病18 h以内的脑出血患者。对于纳入研究队列的患者，随机分为去铁胺组与对照组。两组患者基础支持疗法基本相同，去铁胺组患者静脉输注甲磺酸去铁胺。收集患者入院时头颅CT和神经病学量表（ NIHSS 量表、GCS 量表等）评分。1年后随访，应用改良 RANKIN （ mRS）量表对两组患者进行评分，并进行比较。结果研究共纳入42例患者，其中去铁胺组21例，对照组21例，两组患者入院时基线资料差异无统计学意义。1年后，去铁胺组有6例患者mRS≥3，对照组有6例患者mRS≥3。两组患者入院1年mRS评分分布差异无统计学意义（ P＝1．000）。结论甲磺酸去铁胺可能无助于改善脑出血患者的长期预后，确切结论仍需进一步研究。

Objective To study the effect of the deferoxamine mesylate on the prognosis of patients with intracerebral hemorrhage（ICH） after one year. Methods From February 2013 to May 2014,spontaneous ICH patients diagnosed by computed tomography （ CT ） within 18 hours of onset in Mancheng District Hospital of Baoding were evaluated. Patients were randomly divided into experimental group and control group. The treatment of the two groups was similar except that the experimental group received deferoxamine mesylate. Patients were e？valuated by CT and neurology scale（ NIHSS scale,GCS scale） at the time of admission and followed up for the first year by the RANKIN（ mRS） scale. All clinical data of the two groups were compared. Results Forty？two patients were included in the study, including 21 cases in the experimental group and 21 cases in the control group,there was no significant difference in baseline data between the two groups at admission. There were 6 pa？tients with mRS ≥3 in the experimental group, and 6 patients with mRS ≥3 in the control group after one year. There was no statistically significant difference in the distribution of mRS score between the two groups after one year admission（ P=1. 000） . Conclusion There may be no helpful on the prognosis of patients with intrace？rebral hemorrhage by intravenous infusion of deferoxamine mesylate,the further study is needed.